Immunogen sequence: ETEEGNGVETE DGAASPRVLT PTLALTLPP
Highest antigen sequence identity to the following orthologs - mouse 67%, rat 70%.
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium.
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Protein Aliases: ATP-sensitive inward rectifier potassium channel 14; Inward rectifier K(+) channel Kir2.4; inwardly rectifying potassium channel KIR2.4; IRK-4; Potassium channel, inwardly rectifying subfamily J member 14; potassium channel, inwardly rectifying subfamily J, member 14; potassium inwardly-rectifying channel, subfamily J, member 14
Gene Aliases: IRK4; KCNJ14; KIR2.4
UniProt ID: (Human) Q9UNX9
Entrez Gene ID: (Human) 3770