Immunogen sequence: ILSTSYNRFR KFPFFTRPLL SKWCPKSLFK KKPDPKPADE AVPQIIISAE ELPGPKLGTC PSR
Highest antigen sequence identity to the following orthologs: Mouse - 37%, Rat - 48%.
TRESK (TWIK-related spinal cord K+ channel) is a two-pore domain K+ channel that induces outward rectification and functions as a background K+ channel that is abundantly expressed in the spinal cord, thymus, spleen, and leukemic T-lymphocytes. TRESK is activated by increased cytoplasmic calcium concentration through calcineurin as well as by acetylcholine and histamine. It has been suggested that TRESK is linked to acute and chronic pain by activation of calcineurin. Other studies indicate that TRESK may play a role in the regulation of T-cell function and could be an excellent target to treat T-cell originated immune dysfunction.
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Protein Aliases: K2p18.1, MGR13, TRESK, TRESK-2, TRESK2, TRIK; Potassium channel subfamily K member 18; potassium channel, subfamily K, member 18; potassium channel, two pore domain subfamily K, member 18; TWIK-related individual K+ channel; TWIK-related individual potassium channel; TWIK-related spinal cord K+ channel; TWIK-related spinal cord potassium channel
Gene Aliases: K2p18.1; KCNK18; MGR13; TRESK; TRESK-2; TRESK2; TRIK
UniProt ID: (Human) Q7Z418
Entrez Gene ID: (Human) 338567