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Product Details
OSP00105W-100UL
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:2,000 | - |
Immunohistochemistry (IHC) |
1:2,000 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Mouse, Non-human primate, Rat |
Host/Isotype |
Rabbit / Ig |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
A synthetic peptide from rat KCNMA1 conjugated to blue carrier protein was used as the antigen |
Conjugate |
Unconjugated |
Form |
Lyophilized |
Storage buffer |
whole serum |
Contains |
no preservative |
Storage conditions |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in mouse.
Specificity of this antibody: KCNMA1.
Target Information
Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BK channel; BK channel alpha subunit; BKCA alpha; calcium-activated potassium channel alpha subunit; Calcium-activated potassium channel subunit alpha-1; Calcium-activated potassium channel, subfamily M subunit alpha-1; K(VCA)alpha; KCa1.1; Maxi K channel; MaxiK; mSlo1; potassium large conductance calcium-activated channel, subfamily M, alpha member 1; Slo homolog; Slo-alpha; Slo1; Slowpoke homolog
Gene Aliases: 5730414M22Rik; BKCa; Kcnma; Kcnma1; KCNMA1b; KCNMA1c; MaxiK; mSlo; mSlo1; Slo; Slo1
UniProt ID: (Mouse) Q08460, (Rat) Q62976
Entrez Gene ID: (Mouse) 16531, (Rat) 83731
Molecular Function:
ion channel
response to hypoxia
transport
ion transport
potassium ion transport
response to osmotic stress
chemical synaptic transmission
sensory perception of sound
circadian rhythm
adult walking behavior
response to pH
neuronal action potential
cellular potassium ion homeostasis
response to corticosteroid
regulation of aldosterone metabolic process
response to carbon monoxide
regulation of ion transmembrane transport
vasodilation
regulation of vasodilation
regulation of membrane potential
auditory receptor cell differentiation
positive regulation of apoptotic process
response to estrogen
locomotor rhythm
negative regulation of cell volume
saliva secretion
cell maturation
neuromuscular process controlling balance
protein homooligomerization
protein homotetramerization
response to calcium ion
transmembrane transport
micturition
eye blink reflex
smooth muscle contraction involved in micturition
relaxation of vascular smooth muscle
potassium ion transmembrane transport
actin binding
ion channel activity
voltage-gated ion channel activity
voltage-gated potassium channel activity
potassium channel activity
protein binding
calcium-activated potassium channel activity
protein complex binding
protein homodimerization activity
metal ion binding
large conductance calcium-activated potassium channel activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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