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Product Details
PA5-41071
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
0.2-1 µg/mL | - |
Immunohistochemistry (IHC) |
1:300 | - |
Immunocytochemistry (ICC/IF) |
1:300 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Synthetic peptide directed towards the middle region of human KCNN2 |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.5 mg/mL |
Purification |
Affinity Chromatography |
Storage buffer |
PBS with 2% sucrose |
Contains |
0.09% sodium azide |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2605451 |
Product Specific Information
Peptide sequence: KNAAANVLRE TWLIYKNTKL VKKIDHAKVR KHQRKFLQAI HQLRSVKMEQ
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%
Target Information
Action potentials in vertebrate neurons are followed by an afterhyperpolarization that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: apamin-sensitive small-conductance Ca2+-activated potassium channel; KCa2.2; potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2; SK2; small conductance calcium-activated potassium channel 2; Small conductance calcium-activated potassium channel protein 2
Gene Aliases: hSK2; KCa2.2; KCNN2; SK2; SKCa 2; SKCA2
UniProt ID: (Human) Q9H2S1
Entrez Gene ID: (Human) 3781
Molecular Function:
voltage-gated ion channel
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