Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Keep as concentrated solution.
Predicted reactivity: Mouse (98%), Rat (97%), Dog (99%), Chicken (95%), Rhesus Monkey (99%), Bovine (99%).
Positive Control: 293T, A431, Raji, mouse brain.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Voltage-gated potassium (Kv) channels are key components of the potassium currents in the heart and central nervous system. In the heart, Kv4 channels are involved in the repolarization phase of the action potential. In the brain however, these channels prevent reverse-propagation of action potentials. Found associated with Kv4 channels are a group of calcium-binding proteins termed KChIPs (Kv channel interacting proteins). KChIPs are small molecular weight proteins that bind to the cytoplasmic amino termini of Kv4 alpha-subunits and help to modulate its function. There are currently three known KChIPs; KChIP1 expressed in the brain; KChIP2 expressed in the brain, heart, and lung, and has three isoforms, a, b, and c; and KChIP3, also known as calsenilin and DREAM (downstream regulatory elements (DRE)-antagonist modulator) which is expressed in the brain and testis.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: A-type potassium channel modulatory protein 2; A-type potassium channel modulatory protein KCNIP2; Cardiac voltage-gated potassium channel modulatory subunit; DKFZp566L1246; KChIP2; KChlP2; Kv channel interacting protein 2; Kv channel-interacting protein 2; MGC17241; Potassium channel-interacting protein 2
Gene Aliases: KCHIP2; KCNIP2
UniProt ID: (Human) Q9NS61, (Mouse) Q9JJ69
Entrez Gene ID: (Human) 30819, (Mouse) 80906
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