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Invitrogen
KChIP2 Polyclonal Antibody
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Product Details
PA5-85434
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human KChIP2. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Keep as concentrated solution.
Predicted reactivity: Mouse (98%), Rat (97%), Dog (99%), Chicken (95%), Rhesus Monkey (99%), Bovine (99%).
Positive Control: 293T, A431, Raji, mouse brain.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Voltage-gated potassium (Kv) channels are key components of the potassium currents in the heart and central nervous system. In the heart, Kv4 channels are involved in the repolarization phase of the action potential. In the brain however, these channels prevent reverse-propagation of action potentials. Found associated with Kv4 channels are a group of calcium-binding proteins termed KChIPs (Kv channel interacting proteins). KChIPs are small molecular weight proteins that bind to the cytoplasmic amino termini of Kv4 alpha-subunits and help to modulate its function. There are currently three known KChIPs; KChIP1 expressed in the brain; KChIP2 expressed in the brain, heart, and lung, and has three isoforms, a, b, and c; and KChIP3, also known as calsenilin and DREAM (downstream regulatory elements (DRE)-antagonist modulator) which is expressed in the brain and testis.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A-type potassium channel modulatory protein 2; A-type potassium channel modulatory protein KCNIP2; Cardiac voltage-gated potassium channel modulatory subunit; DKFZp566L1246; KChIP; KChIP2; KCHIP2.2; KChlP2; KCNIP2-Ia; KCNIP2-Ia#IIab; KCNIP2-Ia#IIb; KCNIP2-Ib#IIab; KCNIP2-Ic#IIab; Kv channel interacting protein 2; Kv channel-interacting protein 2; MGC17241; neuronal calcium sensor-1 homolog; potassium channel interacting protein; KChIP2; Potassium channel-interacting protein 2; unnamed protein product
Gene Aliases: KCHIP2; KCNIP2
UniProt ID: (Human) Q9NS61, (Mouse) Q9JJ69
Entrez Gene ID: (Human) 30819, (Mouse) 80906
A-type (transient outward) potassium channel activity
potassium channel activity
calcium ion binding
protein binding
potassium channel regulator activity
identical protein binding
ion channel binding
macromolecular complex binding
metal ion binding
ER retention sequence binding
voltage-gated ion channel activity
protein N-terminus binding
action potential
detection of calcium ion
ion transport
potassium ion transport
muscle contraction
signal transduction
chemical synaptic transmission
regulation of heart contraction
regulation of signal transduction
ion transmembrane transport
clustering of voltage-gated potassium channels
regulation of membrane repolarization
potassium ion transmembrane transport
membrane repolarization
membrane repolarization during cardiac muscle cell action potential
regulation of potassium ion transmembrane transport
regulation of potassium ion export across plasma membrane
positive regulation of potassium ion export across plasma membrane
transport
regulation of ion transmembrane transport
potassium ion export
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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