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Invitrogen

KDEL Polyclonal Antibody

View all (21) KDEL antibodies

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KDEL Polyclonal Antibody

Product Details

PA5-116311

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide between 185-211 amino acids from the C-terminal region of human KDELR1
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

Protein A, Antigen affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2900945

Target Information

The sequence Lys-Asp-Glu-Leu (KDEL) or a closely related sequence, is present at the carboxy-terminus of soluble endoplasmic reticulum (ER) resident proteins and some membrane proteins. 78 and 94 kDa glucose regulated proteins, GRP78 and GRP94 respectively, and protein disulfide isomerase (PDI) all share the C-terminal KDEL sequence. The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 78 kDa glucose-regulated protein; 94 kDa glucose-regulated protein; Binding-immunoglobulin protein; BiP; chaperone; Endoplasmic reticulum chaperone BiP; endoplasmic reticulum lumenal Ca(2+)-binding protein grp78; Endoplasmin; endothelial cell (HBMEC) glycoprotein; epididymis luminal protein 35; epididymis secretory sperm binding protein Li 125m; epididymis secretory sperm binding protein Li 89n; ER lumen protein-retaining receptor 1; glucose-regulated protein (grp78); glucose-regulated protein, 78kDa; gp96 homolog; GRP-78; GRP-94; heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Heat shock protein 70 family protein 5; Heat shock protein 90 kDa beta member 1; heat shock protein 90kDa beta (Grp94), member 1; heat shock protein 90kDa beta family member 1; Heat shock protein family A member 5; Heat shock protein family C member 4; HSP70 family protein 5; Immunoglobulin heavy chain-binding protein; KDEL; KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1; KDEL endoplasmic reticulum protein retention receptor 1; KDEL receptor 1; Lys-Asp-Glu-Leu; Putative MAPK-activating protein PM23; RP23-446N16.1; stress-inducible tumor rejection antigen gp96; tumor rejection antigen (gp96) 1; Tumor rejection antigen 1; unnamed protein product

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Gene Aliases: BIP; ECGP; ERD2; ERD2.1; GP96; GRP78; GRP94; HDEL; HEL-S-125m; HEL-S-89n; HEL35; HSP90B1; HSPA5; HSPC4; KDELR1; PM23; TRA1

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UniProt ID: (Human) P14625, (Human) P11021, (Human) P24390

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Entrez Gene ID: (Human) 7184, (Human) 3309, (Human) 10945

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Function(s)
nucleotide binding RNA binding protein phosphatase inhibitor activity calcium ion binding protein binding ATP binding hydrolase activity ATPase activity protein phosphatase binding protein binding involved in protein folding low-density lipoprotein particle receptor binding unfolded protein binding ATP-dependent protein folding chaperone enzyme binding protein domain specific binding protein serine/threonine kinase inhibitor activity heat shock protein binding ubiquitin protein ligase binding ribosome binding cadherin binding chaperone binding misfolded protein binding KDEL sequence binding ER retention sequence binding
Process(es)
translational initiation protein folding ER overload response cerebellum structural organization cerebellar Purkinje cell layer development substantia nigra development positive regulation of cell migration negative regulation of transforming growth factor beta receptor signaling pathway endoplasmic reticulum unfolded protein response posttranslational protein targeting to membrane, translocation negative regulation of protein complex assembly positive regulation of protein ubiquitination protein folding in endoplasmic reticulum response to endoplasmic reticulum stress maintenance of protein localization in endoplasmic reticulum IRE1-mediated unfolded protein response PERK-mediated unfolded protein response ERAD pathway protein refolding cellular response to glucose starvation negative regulation of apoptotic process positive regulation of transcription from RNA polymerase II promoter proteolysis involved in cellular protein catabolic process regulation of protein folding in endoplasmic reticulum cellular response to interleukin-4 regulation of ATF6-mediated unfolded protein response regulation of IRE1-mediated unfolded protein response negative regulation of IRE1-mediated unfolded protein response regulation of PERK-mediated unfolded protein response negative regulation of PERK-mediated unfolded protein response response to hypoxia protein transport positive regulation of Wnt signaling pathway retrograde protein transport, ER to cytosol actin rod assembly positive regulation of toll-like receptor signaling pathway sequestering of calcium ion cellular response to manganese ion cellular response to ATP protein localization to plasma membrane protein retention in ER lumen retrograde vesicle-mediated transport, Golgi to ER vesicle-mediated transport T cell differentiation T cell apoptotic process
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