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Active Motif
KDM1B / LSD2 Polyclonal Antibody
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Product Details
61457
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
This antibody was raised against a peptide within the N-terminal region of mouse kDM1B / LSD2.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Purification
Antigen affinity chromatography, Affinity chromatography
Storage buffer
PBS, pH 7.5, with 30% glycerol
Contains
0.035% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
The KDM1B gene, also known as lysine demethylase 1B, or LSD2/AOF1, encodes a histone demethylase that specifically targets H3K4me1/2 marks, which are critical for regulating gene expression. KDM1B is an epigenetic modifier that plays a pivotal role in modulating chromatin structure and, consequently, gene transcription. Unlike its homolog KDM1A, KDM1B associates mainly with the gene bodies of actively transcribed genes rather than promoters, indicating its unique role in transcriptional regulation. KDM1B is implicated in various physiological processes and pathophysiological conditions, including tumor progression where it enhances somatic cell reprogramming and promotes the enrichment of tumor stem cells. Its demethylation activity against histones H3K4 and H3K9 underscores its influence on gene silencing and activation pathways, marking it as a significant target in cancer research and potential therapeutic interventions. Understanding the structural and functional nuances of KDM1B contributes to broader insights into epigenetic regulation mechanisms and their implications in disease states.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: amine oxidase, flavin containing 1; Flavin-containing amine oxidase domain-containing protein 1; Lysine-specific histone demethylase 1B; Lysine-specific histone demethylase 2
Gene Aliases: 4632428N09Rik; AI482520; Aof1; Kdm1b; Lsd2
UniProt ID: (Mouse) Q8CIG3
Entrez Gene ID: (Mouse) 218214
DNA binding
zinc ion binding
N-ethylmaleimide reductase activity
oxidoreductase activity
histone demethylase activity (H3-trimethyl-K4 specific)
histone demethylase activity (H3-dimethyl-K4 specific)
histone demethylase activity (H3-monomethyl-K4 specific)
reduced coenzyme F420 dehydrogenase activity
sulfur oxygenase reductase activity
malolactic enzyme activity
NADPH:sulfur oxidoreductase activity
metal ion binding
flavin adenine dinucleotide binding
epoxyqueuosine reductase activity
oxidase
oxidoreductase
metabolite interconversion enzyme
regulation of gene expression by genetic imprinting
transcription, DNA-templated
regulation of transcription, DNA-templated
multicellular organism development
chromatin modification
histone H3-K4 demethylation
DNA methylation involved in gamete generation
regulation of DNA methylation
oxidation-reduction process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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