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OriGene

KDR Monoclonal Antibody (OTI2A1), TrueMAB™

View all (70) FLK1 (VEGF Receptor 2) antibodies

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KDR Monoclonal Antibody (OTI2A1), TrueMAB™

Product Details

CF802443

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

OTI2A1

Immunogen

Human recombinant protein fragment corresponding to amino acids 786-1356 of human KDR produced in HEK293T cell.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 8% trehalose

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)

Target Information

KDR (FLK1, VEGFR2) is a type III receptor tyrosine kinase. It binds vascular endothelial growth factor with high affinity in vitro, and is expressed early in development by endothelial cell precursors. FLK1 (VEGF Receptor 2) encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc. Mutations of FLK1 (VEGF Receptor 2) are implicated in infantile capillary hemangiomas.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD309; CD309 antigen; Fetal liver kinase 1; fetal liver kinase-1; FLK-1; KDR; Kinase insert domain receptor; kinase insert domain receptor (a type III receptor tyrosine kinase); Protein-tyrosine kinase receptor flk-1; sCD309; soluble CD309; soluble VEGFR 2; soluble VEGFR2; tyrosine kinase growth factor receptor; unnamed protein product; Vascular endothelial growth factor receptor 2; VEGF R2; VEGFR-2; VEGFR-2; tyrosine kinase

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Gene Aliases: CD309; FLK1; KDR; VEGFR; VEGFR2

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UniProt ID: (Human) P35968

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Entrez Gene ID: (Human) 3791

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Function(s)
nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity vascular endothelial growth factor-activated receptor activity integrin binding protein binding ATP binding coreceptor activity kinase activity transferase activity growth factor binding vascular endothelial growth factor binding identical protein binding cadherin binding Hsp90 protein binding
Process(es)
angiogenesis ovarian follicle development patterning of blood vessels vasculogenesis positive regulation of protein phosphorylation positive regulation of endothelial cell proliferation vasculature development lymph vessel development positive regulation of mesenchymal cell proliferation epithelial cell maturation endocardium development endothelium development transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cell proliferation regulation of cell shape mesenchymal cell proliferation positive regulation of endothelial cell migration negative regulation of gene expression positive regulation of macroautophagy cell migration peptidyl-tyrosine phosphorylation hemopoiesis cell differentiation lung development positive regulation of cell migration positive regulation of BMP signaling pathway embryonic hemopoiesis cellular response to vascular endothelial growth factor stimulus vascular endothelial growth factor receptor-2 signaling pathway vascular endothelial growth factor signaling pathway negative regulation of apoptotic process surfactant homeostasis regulation of MAPK cascade positive regulation of MAPK cascade negative regulation of neuron apoptotic process positive regulation of blood vessel endothelial cell migration cell fate commitment endothelial cell differentiation positive regulation of angiogenesis protein autophosphorylation vascular endothelial growth factor receptor signaling pathway lung alveolus development post-embryonic camera-type eye morphogenesis branching morphogenesis of an epithelial tube epithelial cell proliferation positive regulation of epithelial cell proliferation positive regulation of positive chemotaxis positive regulation of focal adhesion assembly positive regulation of protein kinase B signaling positive regulation of mitochondrial depolarization calcium ion homeostasis epithelial tube morphogenesis blood vessel endothelial cell differentiation vascular wound healing positive regulation of ERK1 and ERK2 cascade semaphorin-plexin signaling pathway stem cell proliferation positive regulation of cell migration involved in sprouting angiogenesis positive regulation of mitochondrial fission positive regulation of nitric oxide-cGMP mediated signal transduction regulation of hematopoietic progenitor cell differentiation regulation of bone development cellular response to hydrogen sulfide negative regulation of endothelial cell apoptotic process positive regulation of stem cell proliferation positive regulation of endothelial cell chemotaxis positive regulation of vasculogenesis
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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