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Invitrogen
KIF2A Polyclonal Antibody
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Product Details
PA5-40802
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the N-terminal of human KIF2A (aa 72-121).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Peptide sequence: IEPSPETPPP PASSAKVNKI VKNRRTVASI KNDPPSRDNR VVGSARARPS
Sequence homology: Cow: 86%; Dog: 93%; Guinea Pig: 93%; Horse: 86%; Human: 100%; Mouse: 79%; Rabbit: 93%; Rat: 93%
Target Information
KIF2A, a gene encoding the kinesin family member 2A protein, plays a pivotal role in neuronal development and function. This gene is part of the kinesin-13 subfamily, characterized by its unique ability to depolymerize microtubules, which are essential components of the cytoskeleton responsible for maintaining cell shape, enabling motility, and facilitating intracellular transport. KIF2A is particularly significant in neural settings, where it regulates microtubule dynamics crucial for neuronal migration and dendritic development. Dysfunctional KIF2A, due to mutations, has been linked to early-onset neurodegenerative diseases such as progressive microcephaly and mental disabilities due to impaired microtubule regulation, reflecting its foundational role in correct brain development and architecture. Additionally, KIF2A is involved in spindle assembly and chromosome segregation during cell division, further cementing its importance in both neurodevelopment and general cellular functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hK2; kinesin heavy chain member 2A; Kinesin, heavy chain, 2; Kinesin-2; Kinesin-like protein KIF2A
Gene Aliases: CDCBM3; HK2; KIF2; KIF2A; KNS2
UniProt ID: (Human) O00139
Entrez Gene ID: (Human) 3796
retrograde vesicle-mediated transport, Golgi to ER
microtubule-based movement
mitotic spindle organization
sister chromatid cohesion
nervous system development
antigen processing and presentation of exogenous peptide antigen via MHC class II
cell differentiation
cell division
mitotic spindle assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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