The killer immunoglobulin-like receptors (KIRs) on natural killer (NK) cells regulate the inhibition and activation of NK-cell responses through recognition of human leukocyte antigen (HLA) class I molecules. KIR3DL1, a receptor for HLA-B antigens with the Bw4 allele, transmits an inhibitory signal to prevent killer cell-mediated cytoxicity. KIR3DL1 encodes a 444 amino acid type I transmembrane protein, containing three immunoglobulin-like C2-type domains.
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Protein Aliases: Killer cell immunoglobulin-like receptor 3DS1; killer cell immunoglobulin-like receptor KIR3DS1; killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1; killer Ig receptor; MHC class I NK cell receptor; natural killer cell receptor; Natural killer-associated transcript 10; NKAT-10
Gene Aliases: CD158E2; KIR-123FM; KIR-G1; KIR3DS1; NKAT-10; NKAT10
UniProt ID: (Human) Q14943
Entrez Gene ID: (Human) 3813