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Proteintech
KPNA6 Polyclonal Antibody
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Product Details
12366-2-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KPNA6 Fusion Protein Ag3040 (185-536 aa encoded by BC020520)
Conjugate
Form
Liquid
Concentration
0.19 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: EQAVWALGN IAGDSSVCRD YVLNCSILNP LLTLLTKSTR LTMTRNAVWA LSNLCRGKNP PPEFAKVSPC LPVLSRLLFS SDSDLLADAC WALSYLSDGP NEKIQAVIDS GVCRRLVELL MHNDYKVASP ALRAVGNIVT GDDIQTQVIL NCSALPCLLH LLSSPKESIR KEACWTISNI TAGNRAQIQA VIDANIFPVL IEILQKAEFR TRKEAAWAIT NATSGGTPEQ IRYLVSLGCI KPLCDLLTVM DSKIVQVALN GLENILRLGE QEGKRSGSGV NPYCGLIEEA YGLDKIEFLQ SHENQEIYQK AFDLIEHYFG VEDDDSSLAP QVDETQQQFI FQQPEAPMEG FQL (185-536 aa encoded by BC020520)
Target Information
Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA6 belongs to a subfamily within the KPNA family that also includes IPOA5&6. Down-regulation of KPNA6 by RNAi expression in HeLa cells strongly inhibited cell proliferation, possibly due to blocking the nuclear import of specific factors essential for cell growth and proliferation. KPNA6 also interacts with the Rev protein of HIV-1 and promote its nuclear import.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FLJ11249; importin alpha 7 subunit; Importin subunit alpha-7; importin-alpha-S2; karyopherin alpha 6; karyopherin alpha 6 (importin alpha 7); Karyopherin subunit alpha-6; MGC17918; RP4-622L5.1; unnamed protein product
Gene Aliases: IPOA7; KPNA6
UniProt ID: (Human) O60684
Entrez Gene ID: (Human) 23633
transcription from RNA polymerase II promoter
protein import into nucleus
NLS-bearing protein import into nucleus
protein transport
viral genome replication
positive regulation of transcription from RNA polymerase II promoter
maternal process involved in female pregnancy
entry of viral genome into host nucleus through nuclear pore complex via importin
positive regulation of cytokine production involved in inflammatory response
positive regulation of viral life cycle
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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