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Invitrogen
Kindlin Polyclonal Antibody
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Product Details
PA5149596
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human FERMT1
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ADSLLEDITD IPKLADNLKL FRPKKLLPKA FKQYWFIFKD TSIAYFKNKE LEQGEPL
Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 84%.
Target Information
Kindlin 1 is a member of the kindlin family of focal adhesion proteins and contains a FERM domain and pleckstrin homology domain. It is involved in integrin signaling, linkage of the cytoskeleton to the extracellular matrix, and cell adhesion. It is most often expressed in epithelial cells. When kindlin 1 is coexpressed with talin it helps to activate ITGA2B. It is required for keratinocyte proliferation, polarization of basal keratinocytes in the skin, and for normal cell shape. Mutations in kindlin 1 have been linked to Kindler syndrome, a recessive skin disorder involving blistering, photosensitivity, poikiloderma, and atrophy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Fermitin family homolog 1; fermitin family member 1; FLJ20116; FLJ23423; Kindlerin; kindlin 1; Kindlin syndrome protein; Kindlin-1; RP5-1056H1.1; similar to Caenorhabditis elegans Unc-112 related protein 1; Unc-112-related protein 1; UNC112 related protein 1; unnamed protein product
Gene Aliases: C20orf42; DTGCU2; FERMT1; KIND1; UNC112A; URP1
UniProt ID: (Human) Q9BQL6
Entrez Gene ID: (Human) 55612
positive regulation of cell-matrix adhesion
cell adhesion
cell-matrix adhesion
integrin-mediated signaling pathway
negative regulation of gene expression
positive regulation of cell migration
positive regulation of transforming growth factor beta receptor signaling pathway
positive regulation of integrin activation
positive regulation of cell adhesion mediated by integrin
negative regulation of protein import into nucleus
keratinocyte proliferation
keratinocyte migration
negative regulation of timing of anagen
positive regulation of transforming growth factor beta production
basement membrane organization
negative regulation of canonical Wnt signaling pathway
establishment of epithelial cell polarity
positive regulation of wound healing, spreading of epidermal cells
negative regulation of stem cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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