Proteintech

LAMP3 Polyclonal Antibody

LAMP3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 13

LAMP3 Antibody (12632-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human placenta using 12632-1-AP (LAMP3 antibody) at dilution of 1:50 (under 40x lens).

LAMP3 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

12632-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 8 publications 8 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 9 publications 9 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

LAMP3 Fusion Protein Ag3325 (30-380 aa encoded by BC032940)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: FPGTRDYSQ PTAAATVQDI KKPVQQPAKQ APHQTLAARF MDGHITFQTA ATVKIPTTTP ATTKNTATTS PITYTLVTTQ ATPNNSHTAP PVTEVTVGPS LAPYSLPPTI TPPAHTTGTS SSTVSHTTGN TTQPSNQTTL PATLSIALHK STTGQKPVQP THAPGTTAAA HNTTRTAAPA STVPGPTLAP QPSSVKTGIY QVLNGSRLCI KAEMGIQLIV QDKESVFSPR RYFNIDPNAT QASGNCGTRK SNLLLNFQGG FVNLTFTKDE ESYYISEVGA YLTVSDPETV YQGIKHAVVM FQTAVGHSFK CVSEQSLQLS AHLQVKTTDV QLQAFDFEDD HFGNVDECSS DY (30-380 aa encoded by BC032940)

Target Information

Dendritic cells (DCs) are the most potent antigen-presenting cells. Immature DCs efficiently capture antigens and differentiate into interdigitating dendritic cells (IDCs) in lymphoid tissues that induce primary T-cell responses (summary by de Saint-Vis et al., 1998 [PubMed 9768752]).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Lysosome-Associated Membrane Protein 3 Induces Lysosome-Dependent Cell Death by Impairing Autophagic Caspase 8 Degradation in the Salivary Glands of Individuals With Sjögren's Disease.

Arthritis & rheumatology (Hoboken, N.J.)

Nakamura H,Tanaka T,Zheng C,Afione SA,Warner BM,Noguchi M,Atsumi T,Chiorini JA

Fri Sep 01 00:00:00 UTC 2023

LAMP3 transfer via extracellular particles induces apoptosis in Sjögren's disease.

Scientific reports

Tanaka T,Nakamura H,Tran DT,Warner BM,Wang Y,Atsumi T,Noguchi M,Chiorini JA

Tue Feb 14 00:00:00 UTC 2023

LAMP3 transfer via extracellular particles induces apoptosis in Sjögren's disease.

Scientific reports

Tanaka T,Nakamura H,Tran DT,Warner BM,Wang Y,Atsumi T,Noguchi M,Chiorini JA

Tue Feb 14 00:00:00 UTC 2023

Correction of LAMP3-associated salivary gland hypofunction by aquaporin gene therapy.

Scientific reports

Nakamura H,Tanaka T,Zheng C,Afione SA,Warner BM,Noguchi M,Atsumi T,Chiorini JA

Thu Nov 03 00:00:00 UTC 2022

LAMP3 inhibits autophagy and contributes to cell death by lysosomal membrane permeabilization.

Autophagy

Tanaka T,Warner BM,Michael DG,Nakamura H,Odani T,Yin H,Atsumi T,Noguchi M,Chiorini JA

Fri Jul 01 00:00:00 UTC 2022

LAMP3 inhibits autophagy and contributes to cell death by lysosomal membrane permeabilization.

Autophagy

Tanaka T,Warner BM,Michael DG,Nakamura H,Odani T,Yin H,Atsumi T,Noguchi M,Chiorini JA

Fri Jul 01 00:00:00 UTC 2022

Lysosomal exocytosis of HSP70 stimulates monocytic BMP6 expression in Sjögren's syndrome.

The Journal of clinical investigation

Mo YQ,Nakamura H,Tanaka T,Odani T,Perez P,Ji Y,French BN,Pranzatelli TJ,Michael DG,Yin H,Chow SS,Khalaj M,Afione SA,Zheng C,Oliveira FR,Motta ACF,Ribeiro-Silva A,Rocha EM,Nguyen CQ,Noguchi M,Atsumi T,Warner BM,Chiorini JA

Tue Mar 15 00:00:00 UTC 2022

Lysosomal exocytosis of HSP70 stimulates monocytic BMP6 expression in Sjögren's syndrome.

The Journal of clinical investigation

Tue Mar 15 00:00:00 UTC 2022

Characterization of the tumour microenvironment phenotypes in malignant tissues and pleural effusion from advanced osteoblastic osteosarcoma patients.

Clinical and translational medicine

Zhang Z,Ji W,Huang J,Zhang Y,Zhou Y,Zhang J,Dong Y,Yuan T,Yang Q,Ding X,Tang L,Li H,Yin J,Wang Y,Ji T,Fei J,Zhang B,Chen P,Hu H

Tue Nov 01 00:00:00 UTC 2022

Upregulation of ATF4-LAMP3 Axis by ORF45 Facilitates Lytic Replication of Kaposi's Sarcoma-Associated Herpesvirus.

Journal of virology

Sun Q,Wang F,Chen Q,Sarid R,Li X,Kuang E

Wed Dec 14 00:00:00 UTC 2022

Intrapulmonary distal airway stem cell transplantation repairs lung injury in chronic obstructive pulmonary disease.

Cell proliferation

Wang X,Zhao Y,Li D,Feng Y,Xie Y,Zhou Y,Zhou M,Wang Y,Qu J,Zuo W

Tue Jun 01 00:00:00 UTC 2021

Differences in the Immune Response of the Nonmetastatic Axillary Lymph Nodes between Triple-Negative and Luminal A Breast Cancer Surrogate Subtypes.

The American journal of pathology

López C,Gibert-Ramos A,Bosch R,Korzynska A,García-Rojo M,Bueno G,García-Fontgivell JF,Martínez González S,Fontoura L,Gras Navarro A,Sauras Colón E,Casanova Ribes J,Roszkowiak L,Roso A,Berenguer M,Llobera M,Baucells J,Lejeune M

Mon Mar 01 00:00:00 UTC 2021

Peritumoral immune infiltrates in primary tumours are not associated with the presence of axillary lymph node metastasis in breast cancer: a retrospective cohort study.

PeerJ

López C,Bosch-Príncep R,Orero G,Fontoura Balagueró L,Korzynska A,García-Rojo M,Bueno G,Fernández-Carrobles MDM,Roszkowiak L,Callau Casanova C,Salvadó-Usach MT,Jaén Martínez J,Gibert-Ramos A,Roso-Llorach A,Gras Navarro A,Berenguer-Poblet M,Llobera M,Gil Garcia J,Tomás B,Gestí V,Laine E,Plancoulaine B,Baucells J,Lejeune M

Sun Apr 17 00:00:00 UTC 2022

Dstyk mutation leads to congenital scoliosis-like vertebral malformations in zebrafish via dysregulated mTORC1/TFEB pathway.

Nature communications

Sun X,Zhou Y,Zhang R,Wang Z,Xu M,Zhang D,Huang J,Luo F,Li F,Ni Z,Zhou S,Chen H,Chen S,Chen L,Du X,Chen B,Huang H,Liu P,Yin L,Qiu J,Chen D,Deng C,Xie Y,Luo L,Chen L

Fri Jan 24 00:00:00 UTC 2020

The Immune Response in Nonmetastatic Axillary Lymph Nodes Is Associated with the Presence of Axillary Metastasis and Breast Cancer Patient Outcome.

The American journal of pathology

López C,Bosch R,Orero G,Korzynska A,García-Rojo M,Bueno G,Fernández-Carrobles MDM,Gibert-Ramos A,Roszkowiak L,Callau C,Fontoura L,Salvadó MT,Álvaro T,Jaén J,Roso-Llorach A,Llobera M,Gil J,Onyos M,Plancoulaine B,Baucells J,Lejeune M

Sun Mar 01 00:00:00 UTC 2020

Alveolar Differentiation Potency of Human Distal Airway Stem Cells Is Associated with Pulmonary Pathological Conditions.

Stem cells international

Wang Y,Lu Y,Wu Y,Sun Y,Zhou Y,Ma Q,Zheng Y,Yu Q,Cao Y,Chen G,Zhang T,Dai X,Ren T,Ma Y,Zuo W

Sat Apr 09 00:00:00 UTC 2022

Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons.

Nature medicine

Shi Y,Lin S,Staats KA,Li Y,Chang WH,Hung ST,Hendricks E,Linares GR,Wang Y,Son EY,Wen X,Kisler K,Wilkinson B,Menendez L,Sugawara T,Woolwine P,Huang M,Cowan MJ,Ge B,Koutsodendris N,Sandor KP,Komberg J,Vangoor VR,Senthilkumar K,Hennes V,Seah C,Nelson AR,Cheng TY,Lee SJ,August PR,Chen JA,Wisniewski N,Hanson-Smith V,Belgard TG,Zhang A,Coba M,Grunseich C,Ward ME,van den Berg LH,Pasterkamp RJ,Trotti D,Zlokovic BV,Ichida JK

Thu Mar 01 00:00:00 UTC 2018

Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons.

Nature medicine

Thu Mar 01 00:00:00 UTC 2018

Regeneration of functional alveoli by adult human SOX9⁺ airway basal cell transplantation.

Protein & cell

Ma Q,Ma Y,Dai X,Ren T,Fu Y,Liu W,Han Y,Wu Y,Cheng Y,Zhang T,Zuo W

Thu Mar 01 00:00:00 UTC 2018

Regeneration of functional alveoli by adult human SOX9⁺ airway basal cell transplantation.

Protein & cell

Ma Q,Ma Y,Dai X,Ren T,Fu Y,Liu W,Han Y,Wu Y,Cheng Y,Zhang T,Zuo W

Thu Mar 01 00:00:00 UTC 2018

Autophagy activation is required for influenza A virus-induced apoptosis and replication.

Biochimica et biophysica acta. Molecular cell research

Yeganeh B,Ghavami S,Rahim MN,Klonisch T,Halayko AJ,Coombs KM

Thu Feb 01 00:00:00 UTC 2018

Autophagy activation is required for influenza A virus-induced apoptosis and replication.

Biochimica et biophysica acta. Molecular cell research

Yeganeh B,Ghavami S,Rahim MN,Klonisch T,Halayko AJ,Coombs KM

Thu Feb 01 00:00:00 UTC 2018

Suppression of influenza A virus replication in human lung epithelial cells by noncytotoxic concentrations bafilomycin A1.

American journal of physiology. Lung cellular and molecular physiology

Yeganeh B,Ghavami S,Kroeker AL,Mahood TH,Stelmack GL,Klonisch T,Coombs KM,Halayko AJ

Sun Feb 01 00:00:00 UTC 2015

Suppression of influenza A virus replication in human lung epithelial cells by noncytotoxic concentrations bafilomycin A1.

American journal of physiology. Lung cellular and molecular physiology

Yeganeh B,Ghavami S,Kroeker AL,Mahood TH,Stelmack GL,Klonisch T,Coombs KM,Halayko AJ

Sun Feb 01 00:00:00 UTC 2015

Diminished parkin solubility and co-localization with intraneuronal amyloid-β are associated with autophagic defects in Alzheimer's disease.

Journal of Alzheimer's disease : JAD

Lonskaya I,Shekoyan AR,Hebron ML,Desforges N,Algarzae NK,Moussa CE

Tue Sep 24 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: CD208; DC LAMP; DC-lysosome-associated membrane glycoprotein; dendritic cells-lysosome associated membrane glycoprotein; LAMP-3; lysosomal-associated membrane protein 3; Lysosome-associated membrane glycoprotein 3; Protein TSC403

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Gene Aliases: 1200002D17Rik; CD208; DC LAMP; DC-LAMP; DCLAMP; LAMP; LAMP-3; LAMP3; TSC403

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UniProt ID: (Human) Q9UQV4, (Rat) Q5XI99, (Mouse) Q7TST5

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Entrez Gene ID: (Human) 27074, (Rat) 303801, (Mouse) 239739

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Function(s)

molecular_function membrane trafficking regulatory protein

Process(es)

adaptive immune response regulation of autophagy positive regulation of gene expression response to interferon-alpha negative regulation of cysteine-type endopeptidase activity involved in apoptotic process viral entry into host cell negative regulation of proteasomal protein catabolic process regulation of viral life cycle immune system process biological_process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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LAMP3 Polyclonal Antibody

LAMP3 Antibody (12632-1-AP) in IHC (P)

Product Details

12632-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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