This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. Alternatively spliced transcript variants of this gene have been found; however, their full-length nature is not known.
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Protein Aliases: cytoplasmic leucyl-tRNA synthetase; cytosolic leucyl-tRNA synthetase; leucine translase; leucine tRNA ligase 1, cytoplasmic; Leucine--tRNA ligase, cytoplasmic; leucine-tRNA ligase; Leucyl-tRNA synthetase; leucyl-tRNA synthetase, cytoplasmic; LeuRS; proliferation-inducing gene 44
Gene Aliases: 2310045K21Rik; 3110009L02Rik; AW536573; hr025Cl; HSPC192; ILFS1; KIAA1352; LARS; LARS1; LEURS; LEUS; LFIS; LRS; mKIAA1352; PIG44; RNTLS