Proteintech

LARS Polyclonal Antibody

LARS Antibody in Immunocytochemistry (ICC/IF)

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LARS Antibody (21146-1-AP) in ICC/IF

Immunofluorescent analysis of (4% PFA) fixed HeLa cells using LARS antibody (Product # 21146-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L), CL594-Phalloidin (red).

LARS Antibody in Immunohistochemistry (Paraffin) (IHC (P))

LARS Antibody in Immunoprecipitation (IP)

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Product Details

21146-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 7 publications 7 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:400

Immunocytochemistry (ICC/IF)

1:10-1:100

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

LARS Fusion Protein Ag15684 (827-1176 aa encoded by BC151214)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.16 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: EFQAAKDKY RELAVEGMHR ELVFRFIEVQ TLLLAPFCPH LCEHIWTLLG KPDSIMNASW PVAGPVNEVL IHSSQYLMEV THDLRLRLKN YMMPAKGKKT DKQPLQKPSH CTIYVAKNYP PWQHTTLSVL RKHFEANNGK LPDNKVIASE LGSMPELKKY MKKVMPFVAM IKENLEKMGP RILDLQLEFD EKAVLMENIV YLTNSLELEH IEVKFASEAE DKIREDCCPG KPLNVFRIEP GVSVSLVNPQ PSNGHFSTKI EIRQGDNCDS IIRRLMKMNR GIKDLSKVKL MRFDDPLLGP RRVPVLGKEY TEKTPISEHA VFNVDLMSKK IHLTENGIRV DIGDTIIYLV H (827-1176 aa encoded by BC151214)

Target Information

This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. Alternatively spliced transcript variants of this gene have been found; however, their full-length nature is not known.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Dickkopf 4 Alone and in Combination with Leucyl-tRNA Synthetase as a Good Prognostic Biomarker for Human Colorectal Cancer.

BioMed research international

Park SJ,Cho JG,Han SH,Kim YM,Pak MG,Roh MS,Park JI

Wed Apr 26 00:00:00 UTC 2023

METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism.

Cell stem cell

Han L,Dong L,Leung K,Zhao Z,Li Y,Gao L,Chen Z,Xue J,Qing Y,Li W,Pokharel SP,Gao M,Chen M,Shen C,Tan B,Small A,Wang K,Zhang Z,Qin X,Yang L,Wunderlich M,Zhang B,Mulloy JC,Marcucci G,Chen CW,Wei M,Su R,Chen J,Deng X

Thu Jan 05 00:00:00 UTC 2023

KAT7-mediated CANX (calnexin) crotonylation regulates leucine-stimulated MTORC1 activity.

Autophagy

Yan G,Li X,Zheng Z,Gao W,Chen C,Wang X,Cheng Z,Yu J,Zou G,Farooq MZ,Zhu X,Zhu W,Zhong Q,Yan X

Thu Dec 01 00:00:00 UTC 2022

A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids.

Nature cell biology

Gollwitzer P,Grützmacher N,Wilhelm S,Kümmel D,Demetriades C

Thu Sep 01 00:00:00 UTC 2022

PGC-1α Regulates Cell Proliferation, Migration, and Invasion by Modulating Leucyl-tRNA Synthetase 1 Expression in Human Colorectal Cancer Cells.

Cancers

Cho JG,Park SJ,Han SH,Park JI

Tue Dec 27 00:00:00 UTC 2022

Identification of LARS as an essential gene for osteosarcoma proliferation through large-Scale CRISPR-Cas9 screening database and experimental verification.

Journal of translational medicine

Chen W,Lin Y,Jiang M,Wang Q,Shu Q

Fri Aug 12 00:00:00 UTC 2022

Identification of LARS as an essential gene for osteosarcoma proliferation through large-Scale CRISPR-Cas9 screening database and experimental verification.

Journal of translational medicine

Chen W,Lin Y,Jiang M,Wang Q,Shu Q

Fri Aug 12 00:00:00 UTC 2022

Multimodal cotranslational interactions direct assembly of the human multi-tRNA synthetase complex.

Proceedings of the National Academy of Sciences of the United States of America

Khan K,Long B,Gogonea V,Deshpande GM,Vasu K,Fox PL

Tue Sep 06 00:00:00 UTC 2022

A genome-wide siRNA screen in mammalian cells for regulators of S6 phosphorylation.

PloS one

Papageorgiou A,Rapley J,Mesirov JP,Tamayo P,Avruch J

Fri Apr 29 00:00:00 UTC 2016

A genome-wide siRNA screen in mammalian cells for regulators of S6 phosphorylation.

PloS one

Papageorgiou A,Rapley J,Mesirov JP,Tamayo P,Avruch J

Fri Apr 29 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: cytoplasmic leucyl-tRNA synthetase; cytosolic leucyl-tRNA synthetase; leucine translase; leucine tRNA ligase 1, cytoplasmic; Leucine--tRNA ligase, cytoplasmic; leucine-tRNA ligase; Leucyl-tRNA synthetase; LeuRS; proliferation-inducing gene 44

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Gene Aliases: hr025Cl; HSPC192; ILFS1; KIAA1352; LARS; LARS1; LEURS; LEUS; LFIS; LRS; PIG44; RNTLS

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UniProt ID: (Human) Q9P2J5

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Entrez Gene ID: (Human) 51520

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Function(s)

aminoacyl-tRNA editing activity leucine-tRNA ligase activity protein binding ATP binding aminoacyl-tRNA synthetase

Process(es)

tRNA aminoacylation for protein translation leucyl-tRNA aminoacylation regulation of translational fidelity

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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LARS Polyclonal Antibody

LARS Antibody (21146-1-AP) in ICC/IF

Product Details

21146-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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