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Proteintech
LATS1 Polyclonal Antibody, CoraLite® Plus 488
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Product Details
CL488-17049
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
LATS1 fusion protein Ag10709
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MKRSEKPEG YRQMRPKTFP ASNYTVSSRQ MLQEIRESLR NLSKPSDAAK AEHNMSKMST EDPRQVRNPP KFGTHHKALQ EIRNSLLPFA NETNSSRSTS EVNPQMLQDL QAAGFDEEDH LSVACSPISL TKPFLI
Target Information
LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis which is phosphorylated in a cell-cycle dependent manner. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity which indicating a role as a negative regulator of CDC2/cyclin A and the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. LATS1 act as a tumor suppressor and play an important role in the development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: h-warts; Large tumor suppressor homolog 1; LATS (large tumor suppressor, Drosophila) homolog 1; LATS, large tumor suppressor, homolog 1; putative serine threonine kinase; Serine/threonine-protein kinase LATS1; similar to Drosophila warts tumor suppressor; WARTS protein kinase
Gene Aliases: LATS1; WARTS; wts
UniProt ID: (Human) O95835
Entrez Gene ID: (Human) 9113
G1/S transition of mitotic cell cycle
G2/M transition of mitotic cell cycle
sister chromatid segregation
inner cell mass cell fate commitment
inner cell mass cellular morphogenesis
protein phosphorylation
protein localization
hormone-mediated signaling pathway
regulation of transforming growth factor beta receptor signaling pathway
keratinocyte differentiation
regulation of actin filament polymerization
regulation of intracellular estrogen receptor signaling pathway
hippo signaling
positive regulation of hippo signaling
positive regulation of apoptotic process
regulation of protein complex assembly
NLRP3 inflammasome complex assembly
mitotic cell cycle phase transition
negative regulation of cyclin-dependent protein serine/threonine kinase activity
regulation of organ growth
cell division
mammary gland epithelial cell differentiation
negative regulation of canonical Wnt signaling pathway
regulation of postsynaptic density assembly
negative regulation of protein localization to nucleus
positive regulation of NLRP3 inflammasome complex assembly
regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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