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Proteintech
LBR Polyclonal Antibody
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Product Details
12398-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
LBR Fusion Protein Ag3088 (1-210 aa encoded by BC020079)
Conjugate
Form
Liquid
Concentration
0.21 mg/mL
Amount
31.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MPSRKFADG EVVRGRWPGS SLYYEVEILS HDSTSQLYTV KYKDGTELEL KENDIKPLTS FRQRKGGSTS SSPSRRRGSR SRSRSRSPGR PPKSARRSAS ASHQADIKEA RREVEVKLTP LILKPFGNSI SRYNGEPEHI ERNDAPHKNT QEKFSLSQES SYIATQYSLR PRREEVKLKE IDSKEEKYVA KELAVRTFEV TPIRAKDLEF G (1-210 aa encoded by BC020079)
Target Information
The protein encoded by this gene belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 3-beta-hydroxysterol Delta (14)-reductase; C-14 sterol reductase; C14SR; Delta(14)-sterol reductase LBR; Delta-14-SR; FLJ43126; ichthyosis; Integral nuclear envelope inner membrane protein; Lamin-B receptor; LMN2R; MGC9041; PRO0650; Sterol C14-reductase; tudor domain containing 18; unnamed protein product
Gene Aliases: AI505894; C14SR; DHCR14B; ic; LBR; LMN2R; Nbp60; PHA; PHASK; TDRD18
UniProt ID: (Human) Q14739, (Mouse) Q3U9G9
Entrez Gene ID: (Human) 3930, (Mouse) 98386, (Rat) 89789
DNA binding
RNA binding
protein binding
lamin binding
oxidoreductase activity
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
delta14-sterol reductase activity
chromo shadow domain binding
NADPH binding
chromatin-protein adaptor activity
nuclear localization sequence binding
poly(A) RNA binding
chaperone binding
reductase
lipid metabolic process
steroid biosynthetic process
cholesterol biosynthetic process
steroid metabolic process
cholesterol metabolic process
sterol biosynthetic process
neutrophil differentiation
random inactivation of X chromosome
oxidation-reduction process
nuclear envelope organization
mitotic nuclear division
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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