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Proteintech
LBR Polyclonal Antibody, CoraLite® Plus 647
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Product Details
CL647-12398
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
654/674 nm
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
PBS with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MPSRKFADGE VVRGRWPGSS LYYEVEILSH DSTSQLYTVK YKDGTELELK ENDIKPLTSF RQRKGGSTSS SPSRRRGSRS RSRSRSPGRP PKSARRSASA SHQADIKEAR REVEVKLTPL ILKPFGNSIS RYNGEPEHIE RNDAPHKNTQ EKFSLSQESS YIATQYSLRP RREEVKLKEI DSKEEKYVAK ELAVRTFEVT PIRAKDLEFG
Target Information
The protein encoded by this gene belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3-beta-hydroxysterol Delta (14)-reductase; C-14 sterol reductase; C14SR; Delta(14)-sterol reductase LBR; Delta-14-SR; FLJ43126; ichthyosis; Integral nuclear envelope inner membrane protein; Lamin-B receptor; LMN2R; MGC9041; PRO0650; Sterol C14-reductase; tudor domain containing 18
Gene Aliases: AI505894; DHCR14B; ic; LBR; LMN2R; Nbp60; PHA; TDRD18
UniProt ID: (Human) Q14739, (Mouse) Q3U9G9
Entrez Gene ID: (Human) 3930, (Mouse) 98386, (Rat) 89789
DNA binding
protein binding
lamin binding
oxidoreductase activity, acting on the CH-CH group of donors
poly(A) RNA binding
delta14-sterol reductase activity
chromo shadow domain binding
nuclear localization sequence binding
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
chaperone binding
reductase
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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