This Antibody was verified by Cell Treatment to ensure that the antibody binds to the antigen stated. View Details
A suggested positive control is human liver tissue lysate.
PA5-20752 can be used with blocking peptide PEP-0866.
The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in the LDL-R gene cause the autosomal dominant disorder, familial hypercholesterolemia. Along with SCARB1, CLDN1, and the tetraspanin superfamily member CD81, LDL-R has been reported to be an entry factor for the Hepatitis C virus. At least three isoforms of LDL-R are known to exist.
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Protein Aliases: FH, FHC, LDLCQ2; LDL receptor; Low-density lipoprotein receptor; low-density lipoprotein receptor class A domain-containing protein 3
Gene Aliases: FH; FHC; Hlb301; LDLCQ2; LDLR; LDLRA