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Proteintech
LEF1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
14972-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
LEF1 Fusion Protein Ag6882 (1-399 aa encoded by BC050632)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.41 mg/mL
Amount
61.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MPQLSGGGG GGGGDPELCA TDEMIPFKDE GDPQKEKIFA EISHPEEEGD LADIKSSLVN ESEIIPASNG HEVARQAQTS QEPYHDKARE HPDDGKHPDG GLYNKGPSYS SYSGYIMMPN MNNDPYMSNG SLSPPIPRTS NKVPVVQPSH AVHPLTPLIT YSDEHFSPGS HPSHIPSDVN SKQGMSRHPP APDIPTFYPL SPGGVGQITP PLGWQGQPVY PITGGFRQPY PSSLSVDTSM SRFSHHMIPG PPGPHTTGIP HPAIVTPQVK QEHPHTDSDL MHVKPQHEQR KEQEPKRPHI KKPLNAFMLY MKEMRANVVA ECTLKESAAI NQILGRRWHA LSREEQAKYY ELARKERQLH MQLYPGWSAR DNYGKKKKRK REKLQESASG TGPRMTAAYI (1-399 aa encoded by BC050632)
Target Information
This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DKFZp586H0919; FLJ46390; HGNC:6551; hLEF-1 isoform; hLEF-1(8A); HMG Binding Domain; HMG box transcription factor; LEF-1; OTTHUMP00000219736; OTTHUMP00000219737; T cell-specific transcription factor 1-alpha; TCF1-alpha; unnamed protein product
Gene Aliases: 3000002B05; ECTD1; ECTD17; LEF-1; TCF10; TCF1ALPHA; TCF7L3
UniProt ID: (Human) Q9UJU2, (Mouse) P27782, (Rat) Q9QXN1
Entrez Gene ID: (Human) 51176, (Mouse) 16842, (Rat) 161452
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription corepressor binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
beta-catenin binding
DNA binding, bending
estrogen receptor binding
histone deacetylase binding
sequence-specific DNA binding
gamma-catenin binding
armadillo repeat domain binding
C2H2 zinc finger domain binding
transcription regulator inhibitor activity
sequence-specific double-stranded DNA binding
transcription regulatory region sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
nucleic acid binding
chromatin binding
negative regulation of transcription from RNA polymerase II promoter
patterning of blood vessels
somitogenesis
epithelial to mesenchymal transition
vasculature development
sprouting angiogenesis
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
cell adhesion
tissue development
positive regulation of gene expression
positive regulation of epithelial to mesenchymal transition
Wnt signaling pathway
dentate gyrus development
hippocampus development
forebrain radial glial cell differentiation
forebrain neuroblast division
formation of radial glial scaffolds
regulation of cell-cell adhesion
regulation of Wnt signaling pathway
cell differentiation
positive regulation of Wnt signaling pathway
neutrophil differentiation
embryonic limb morphogenesis
positive regulation of cell migration
BMP signaling pathway
positive regulation of granulocyte differentiation
mammary gland development
negative regulation of interleukin-13 production
negative regulation of interleukin-4 production
negative regulation of interleukin-5 production
T cell receptor V(D)J recombination
B cell proliferation
odontogenesis of dentin-containing tooth
negative regulation of apoptotic process
tongue development
positive regulation by host of viral transcription
T-helper 1 cell differentiation
positive regulation of gamma-delta T cell differentiation
positive regulation of cell differentiation
negative regulation of striated muscle tissue development
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
alpha-beta T cell differentiation
paraxial mesoderm formation
cell development
regulation of neurogenesis
sensory perception of taste
anatomical structure regression
canonical Wnt signaling pathway
face morphogenesis
cell chemotaxis
apoptotic process involved in morphogenesis
chorio-allantoic fusion
trachea gland development
secondary palate development
protein localization to chromatin
cellular response to cytokine stimulus
cellular response to interleukin-4
positive regulation of cell proliferation in bone marrow
negative regulation of apoptotic process in bone marrow
odontoblast differentiation
positive regulation of cell cycle process
positive regulation of odontoblast differentiation
apoptotic process involved in patterning of blood vessels
positive regulation of chondrocyte proliferation
osteoblast differentiation
negative regulation of DNA binding
positive regulation of endothelial cell-matrix adhesion via fibronectin
kidney development
organ regeneration
skin development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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