Search

  • Statut des commandes
  • Commande rapide
  • Promos

Invitrogen

LEF1 Polyclonal Antibody

View all (51) LEF1 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
{{$ctrl.translations['antibody.pdp.skuNotes.additionalInformation']}}:

{{$ctrl.translations[$ctrl.isSkuNotesCollapsed ? 'antibody.pdp.skuNotes.viewMore' : 'antibody.pdp.skuNotes.viewLess']}}
LEF1 Polyclonal Antibody

Product Details

PA5-85555

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the N-terminus region of human LEF1. The exact sequence is proprietary.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2792695

Product Specific Information

Keep as concentrated solution.

Predicted reactivity: Mouse (93%), Rat (93%), Pig (96%), Bovine (98%).

Positive Control: Jurkat, Juarkat_NE.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: DKFZp586H0919; FLJ46390; HGNC:6551; hLEF-1 isoform; hLEF-1(8A); HMG Binding Domain; HMG box transcription factor; LEF-1; OTTHUMP00000219736; OTTHUMP00000219737; T cell-specific transcription factor 1-alpha; TCF1-alpha; unnamed protein product

View more View less

Gene Aliases: ECTD1; ECTD17; LEF-1; TCF10; TCF1ALPHA; TCF7L3

View more View less

UniProt ID: (Human) Q9UJU2, (Rat) Q9QXN1

View more View less

Entrez Gene ID: (Human) 51176, (Rat) 161452

View more View less

Function(s)
RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription corepressor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding beta-catenin binding DNA binding, bending estrogen receptor binding histone deacetylase binding sequence-specific DNA binding gamma-catenin binding armadillo repeat domain binding C2H2 zinc finger domain binding transcription regulator inhibitor activity sequence-specific double-stranded DNA binding transcription regulatory region sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding chromatin binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter osteoblast differentiation epithelial to mesenchymal transition regulation of transcription from RNA polymerase II promoter positive regulation of gene expression positive regulation of epithelial to mesenchymal transition Wnt signaling pathway cell differentiation neutrophil differentiation positive regulation of cell migration positive regulation of granulocyte differentiation negative regulation of interleukin-13 production negative regulation of interleukin-4 production negative regulation of interleukin-5 production negative regulation of apoptotic process negative regulation of DNA binding positive regulation by host of viral transcription T-helper 1 cell differentiation positive regulation of gamma-delta T cell differentiation positive regulation of cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of neurogenesis canonical Wnt signaling pathway cell chemotaxis secondary palate development protein localization to chromatin cellular response to cytokine stimulus cellular response to interleukin-4 positive regulation of cell proliferation in bone marrow negative regulation of apoptotic process in bone marrow positive regulation of cell cycle process positive regulation of odontoblast differentiation positive regulation of endothelial cell-matrix adhesion via fibronectin patterning of blood vessels somitogenesis kidney development vasculature development sprouting angiogenesis regulation of transcription, DNA-templated cell adhesion tissue development dentate gyrus development hippocampus development forebrain radial glial cell differentiation forebrain neuroblast division formation of radial glial scaffolds regulation of cell-cell adhesion regulation of Wnt signaling pathway positive regulation of Wnt signaling pathway embryonic limb morphogenesis BMP signaling pathway mammary gland development organ regeneration T cell receptor V(D)J recombination B cell proliferation odontogenesis of dentin-containing tooth tongue development skin development negative regulation of striated muscle tissue development alpha-beta T cell differentiation paraxial mesoderm formation cell development sensory perception of taste anatomical structure regression face morphogenesis apoptotic process involved in morphogenesis chorio-allantoic fusion trachea gland development odontoblast differentiation apoptotic process involved in patterning of blood vessels positive regulation of chondrocyte proliferation
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support