The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1.
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Protein Aliases: Basement membrane autoantigen p105; Galectin-3-binding protein; L3 antigen; lectin galactoside-binding soluble 3 binding protein; Lectin galactoside-binding soluble 3-binding protein; lectin, galactoside binding soluble 3 binding protein; lectin, galactoside-binding, soluble, 3 binding protein; mac-2 BP; Mac-2-binding protein; MAC2BP; serum protein 90K; transport and golgi organization 10 homolog B; Tumor-associated antigen 90K
Gene Aliases: 90K; BTBD17B; CyCAP; gp90; LGALS3BP; M2BP; MAC-2-BP; TANGO10B
UniProt ID: (Human) Q08380
Entrez Gene ID: (Human) 3959