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Proteintech
LIG4 Polyclonal Antibody
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Product Details
12695-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
LIG4 Fusion Protein Ag3385 (606-911 aa encoded by BC037491)
Conjugate
Form
Liquid
Concentration
0.21 mg/mL
Amount
31.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: ASGKLASKH LYIGGDDEPQ EKKRKAAPKM KKVIGIIEHL KAPNLTNVNK ISNIFEDVEF CVMSGTDSQP KPDLENRIAE FGGYIVQNPG PDTYCVIAGS ENIRVKNIIL SNKHDVVKPA WLLECFKTKS FVPWQPRFMI HMCPSTKEHF AREYDCYGDS YFIDTDLNQL KEVFSGIKNS NEQTPEEMAS LIADLEYRYS WDCSPLSMFR RHTVYLDSYA VINDLSTKNE GTRLAIKALE LRFHGAKVVS CLAEGVSHVI IGEDHSRVAD FKAFRRTFKR KFKILKESWV TDSIDKCELQ EENQYLI (606-911 aa encoded by BC037491 )
Target Information
The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DNA joinase; DNA ligase (ATP) 4; DNA ligase 4; DNA ligase IV; DNA repair enzyme; ligase IV, DNA, ATP-dependent; Polydeoxyribonucleotide synthase [ATP] 4; polynucleotide ligase; sealase; unnamed protein product
Gene Aliases: 5830471N16Rik; LIG4; LIG4S; tiny
UniProt ID: (Human) P49917, (Mouse) Q8BTF7
Entrez Gene ID: (Human) 3981, (Rat) 290907, (Mouse) 319583
single strand break repair
in utero embryonic development
pro-B cell differentiation
DNA repair
base-excision repair
nucleotide-excision repair, DNA gap filling
double-strand break repair
double-strand break repair via nonhomologous end joining
DNA recombination
cellular response to DNA damage stimulus
central nervous system development
cell proliferation
response to X-ray
response to ionizing radiation
response to gamma radiation
neurogenesis
T cell differentiation in thymus
V(D)J recombination
immunoglobulin V(D)J recombination
T cell receptor V(D)J recombination
somatic stem cell population maintenance
negative regulation of neuron apoptotic process
isotype switching
fibroblast proliferation
positive regulation of fibroblast proliferation
positive regulation of neurogenesis
chromosome organization
cell division
neuron apoptotic process
cellular response to lithium ion
cellular response to ionizing radiation
DNA biosynthetic process
stem cell proliferation
establishment of integrated proviral latency
double-strand break repair via classical nonhomologous end joining
DN2 thymocyte differentiation
positive regulation of chromosome organization
DNA ligation
lagging strand elongation
nucleotide-excision repair
DNA ligation involved in DNA recombination
DNA ligation involved in DNA repair
DNA replication
cell cycle
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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