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Proteintech
LIMD1 Polyclonal Antibody, CoraLite® Plus 488
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Product Details
CL488-28106
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
LIMD1 fusion protein Ag27974
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1000 µg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Sequence of this protein is as follows: MPPQEQRSRP YLHGTRHGSQ DCGSRESLAT SEMSAFHQPG PCEDPSCLTH GDYYDNLSLA SPKWGDKPGV SPSIGLSVGS GWPSSPGSDP PLPKPCGDHP LNHRQLSLSS SRSSEGSLGG QNSGIGGRSS EKPT
Target Information
The Zyxin family of proteins contains five members: Ajuba, Limd1, LPP, TRIP6 and Zyxin. Limd1 (LIM domain-containing protein 1) is a ubiquitously expressed tumor suppressor containing three LIM zinc-binding domains. LIM domains consist of a cysteine-rich consensus sequence containing two distinct zinc-binding subdomains, which mediate protein-protein interactions. Limd1 interacts with the proteins SQSTM1, Rb, p62 and TRAF6. Limd1 was first identified when the deletion of its gene was noted in some cervical cancers. Limd1 blocks in vitro and in vivo tumor growth and is downregulated in lung cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: LIM domain-containing protein 1; LIM domains containing 1
Gene Aliases: LIMD1
UniProt ID: (Human) Q9UGP4
Entrez Gene ID: (Human) 8994
response to hypoxia
osteoblast development
regulation of transcription, DNA-templated
cytoskeleton organization
regulation of cell shape
phosphorylation
cell migration
gene silencing by RNA
cytoplasmic mRNA processing body assembly
gene silencing by miRNA
miRNA mediated inhibition of translation
negative regulation of hippo signaling
negative regulation of osteoblast differentiation
negative regulation of transcription, DNA-templated
negative regulation of canonical Wnt signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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