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Proteintech
LIMPII Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
27102-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
LIMPII Fusion Protein Ag25908 (249-433 aa encoded by BC021892)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.3 mg/mL
Amount
45 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: NGTDGDSFH PLITKDEVLY VFPSDFCRSV YITFSDYESV QGLPAFRYKV PAEILANTSD NAGFCIPEGN CLGSGVLNVS ICKNGAPIIM SFPHFYQADE RFVSAIEGMH PNQEDHETFV DINPLTGIIL KAAKRFQINI YVKKLDDFVE TGDIRTMVFP VMYLNESVHI DKETASRLKS MINTTL (249-433 aa encoded by BC021892)
Target Information
High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. SR-BI and SR-BII (previously known as SR-BI.2) are the alternatively spliced products of a single gene. SR-BII differs from SR-BI in that the encoded c-terminal cytoplasmic domain is almost completely different. SR-BII binds HDLs and mediates selective uptake of HDL cholesteryl ester, but with an approximately 4-fold lower efficiency than SR-BI. Nuclease protection assays show SR-BII to be abundant in mouse tissues expressing SR-BI, with SR-BII expression found in liver, adrenal glands, and testes. Although the role of SR-BII is not completely clear, research suggests that it may be a functional HDL receptor. In addition, SR-BII mRNA results from the alternative splicing of SR-BI precursor transcripts with the SR-BII isoform mediating selective transfer of lipid between HDL and cells. The relative expression and functional activities of these two isoforms create a potential means of regulating selective lipid transfer between HDL and cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 85 kDa lysosomal membrane sialoglycoprotein; 85 kDa lysosomal sialoglycoprotein scavenger receptor class B, member 2; CD 36; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 (lysosomal integral membrane protein II); CD36 antigen-like 2; CD36 molecule; LIMP II; lysosome membrane protein II; sCD 36; sCD36; soluble CD 36; soluble CD36; SR-B2; unnamed protein product
Gene Aliases: 9330185J12Rik; AMRF; CD36L2; EPM4; HLGP85; LGP85; LIMP II; LIMP-2; LIMPII; MLGP85; SR-BII
UniProt ID: (Human) Q14108, (Mouse) O35114
Entrez Gene ID: (Human) 950, (Mouse) 12492
protein targeting to lysosome
receptor-mediated endocytosis
autophagy
positive regulation of neuron projection development
aminophospholipid transport
glycolipid catabolic process
regulation of carbohydrate catabolic process
regulation of endosome organization
regulation of lysosome organization
regulation of glucosylceramide catabolic process
sensory perception of sound
endosome to plasma membrane protein transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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