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Proteintech
LIN28 Polyclonal Antibody
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Product Details
11724-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Dog,
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
LIN28 Fusion Protein Ag2312 (1-209 aa encoded by BC028566)
Conjugate
Form
Liquid
Concentration
0.31 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody is a rabbit polyclonal antibody raised against full length LIN28 of human origin. The calculated molecular weight of LIN28 is 23 kDa, but the modified LIN28 is about 28 kDa.
Immunogen sequence: MGSVSNQQF AGGCAKAAEE APEEAPEDAA RAADEPQLLH GAGICKWFNV RMGFGFLSMT ARAGVALDPP VDVFVHQSKL HMEGFRSLKE GEAVEFTFKK SAKGLESIRV TGPGGVFCIG SERRPKGKSM QKRRSKGDRC YNCGGLDHHA KECKLPPQPK KCHFCQSISH MVASCPLKAQ QGPSAQGKPT YFREEEEEIH SPTLLPEAQN (1-209 aa encoded by BC028566)
Target Information
Lin28 is a transcription factor that was first identified through its key role in the pathway of developmental timing in C. elegans. The role of Lin28 in development suggested that it might be useful in the creation of stem cells that might be beneficial in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing Lin28 in addition to the transcription factors POU5F1, Sox2, and NANOG in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing Lin28, Sox2, POU5F1 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FLJ12457; Lin-28A; Protein lin-28 homolog A; RNA-binding protein LIN-28; testis expressed gene 17; Testis-expressed protein 17; Zinc finger CCHC domain-containing protein 1; zinc finger, CCHC domain containing 1
Gene Aliases: AL024421; CSDD1; ENSMUSG00000070700; Gm10299; LIN-28; lin-28A; LIN28; LIN28A; RGD1566408; Tex17; ZCCHC1
UniProt ID: (Human) Q9H9Z2, (Mouse) Q8K3Y3
Entrez Gene ID: (Human) 79727, (Rat) 500562, (Mouse) 83557
regulation of transcription, DNA-templated
germ cell development
miRNA catabolic process
stem cell population maintenance
pre-miRNA processing
RNA 3'-end processing
somatic stem cell population maintenance
positive regulation of neuron differentiation
negative regulation of glial cell differentiation
positive regulation of translation
stem cell differentiation
regulation of gene silencing by miRNA
positive regulation of cell proliferation involved in kidney development
biological_process
miRNA metabolic process
gene silencing by RNA
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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