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Invitrogen
LIN7A Polyclonal Antibody
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FIGURE: 1 / 8
LIN7A Antibody (PA5-30871) in ICC/IF
LIN7A Polyclonal Antibody detects LIN7A protein at cell membrane by immunofluorescent analysis. Sample: MCF-7 cells were fixed in ice-cold MeOH for 5 min. Green: LIN7A protein stained by LIN7A Polyclonal Antibody (Product # PA5-30871) diluted at 1:1,000. Blue: Hoechst 33342 staining. Scale bar = 10 µm.
Product Details
PA5-30871
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human LIN7A. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 1% BSA, 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: NT2D1, IMR32, U87-MG, MCF-7.
Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (97%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: hLin-7; lin 7 homolog a; Lin-7A; MALS-1; mammalian LIN-7 1; Mammalian lin-seven protein 1; mLin-7; Protein lin-7 homolog A; Tax interaction protein 33; TIP-33; Veli-1; vertebrate homolog of C. elegans Lin-7 type 1; Vertebrate lin-7 homolog 1; vertebrate LIN7 homolog 1
Gene Aliases: AI848705; LIN-7A; LIN7; LIN7A; MALS-1; MALS1; TIP-33; Veli; VELI1
UniProt ID: (Human) O14910, (Mouse) Q8JZS0
Entrez Gene ID: (Human) 8825, (Mouse) 108030
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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