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Invitrogen
LINGO2 Polyclonal Antibody
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FIGURE: 1 / 3
LINGO2 Antibody (PA5-99869) in ICC/IF
Immunofluorescent analysis of LINGO2 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and LINGO2 polyclonal antibody (Product # PA5-99869) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
Product Details
PA5-99869
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human LINGO2(Accession Q7L985), corresponding to amino acid residues L364-E414.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total LINGO2.
Target Information
Leucine-rich repeat and immunoglobulin-like domain-containing protein 2 (LINGO2) is a gene located on chromosome 9q34.3, encoding a transmembrane protein predominantly expressed in the central nervous system. Structurally, LINGO2 features leucine-rich repeat (LRR) domains and immunoglobulin-like domains, which are crucial for molecular interactions and signaling. Functionally, LINGO2 is involved in regulating neural growth and development, influencing processes such as axon guidance and synaptic plasticity. It modulates neurotransmitter receptor activity and intracellular signaling pathways essential for neural transmission, with implications for both normal cognitive function and neurological disorders. Altered expression of LINGO2 has been associated with movement disorders, as well as neurodegenerative conditions, suggesting its role in neural circuit integrity. Current research on LINGO2 is exploring its potential as a therapeutic target for enhancing neural repair mechanisms and addressing synaptic dysfunction, providing insights into interventions for neurological diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: LERN3FLJ31810; leucine rich repeat neuronal 6C; Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2; Leucine-rich repeat neuronal protein 3; Leucine-rich repeat neuronal protein 6C; unnamed protein product
Gene Aliases: B230217C06Rik; LERN3; LINGO2; LRRN6C; RGD1310773; UNQ9234/PRO31993
UniProt ID: (Human) Q7L985, (Mouse) Q3URE9
Entrez Gene ID: (Human) 158038, (Mouse) 242384, (Rat) 313156
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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