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Product Details
PA5-115515
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:1,000-1:3,000 | - |
Immunocytochemistry (ICC/IF) |
1:100-1:500 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
A synthesized peptide derived from human LIS1, corresponding to a region within C-terminal amino acids. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Affinity chromatography |
Storage buffer |
PBS with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
RRID |
AB_2900151 |
Target Information
VAMP7 is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family, localizing to late endosomes and lysosomes. VAMP7 is thought to mediate the fusion of endosomes to their target lysosomes as well as other exocytosis events during phagocytosis and neuritogenesis. VAMP7 interacts with the VPS9 ankyrin repeat protein VARP, a protein that localizes to early endosomes and thought to regulate endosome dynamics. Together with CD82, VAMP7 can modulate the signaling of EGFR by regulating its endocytosis from the plasma membrane.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: LIS-1; LIS-1 {ECO:0000255|HAMAP-Rule:MF_03141}; lissencephaly 1 protein; Lissencephaly-1 protein; lissencephaly-1 protein {ECO:0000255|HAMAP-Rule:MF_03141}; MGC25297; PAF acetylhydrolase 45 kDa subunit; PAF acetylhydrolase 45 kDa subunit {ECO:0000255|HAMAP-Rule:MF_03141}; PAF-AH 45 kDa subunit; PAF-AH 45 kDa subunit {ECO:0000255|HAMAP-Rule:MF_03141}; PAF-AH alpha; PAF-AH alpha {ECO:0000255|HAMAP-Rule:MF_03141}; PAF-AH beta; PAFAH alpha; PAFAH alpha {ECO:0000255|HAMAP-Rule:MF_03141}; PAFAH1B1; platelet-activating factor acetylhydrolase 1b, regulatory subunit 1; platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa); platelet-activating factor acetylhydrolase beta subunit (PAF-AH beta); Platelet-activating factor acetylhydrolase IB subunit alpha; platelet-activating factor acetylhydrolase IB subunit alpha {ECO:0000255|HAMAP-Rule:MF_03141}; Platelet-activating factor acetylhydrolase IB subunit beta; platelet-activating factor acetylhydrolase, isoform 1b, beta1 subunit; platelet-activating factor acetylhydrolase, isoform 1b, subunit 1; platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit (45kD); platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa; platelet-activating factor acetylhydrolase, isoform Ib, subunit 1 (45kDa); RP23-194P5.2
Gene Aliases: LIS-1; LIS1; LIS2; MDCR; MDS; Mdsh; MMS10-U; Ms10u; NudF; PAFAH; PAFAH1B1; PAFAHA
UniProt ID: (Human) P43034, (Rat) P63004, (Mouse) P63005
Entrez Gene ID: (Human) 5048, (Rat) 83572, (Mouse) 18472
establishment of mitotic spindle orientation
microtubule cytoskeleton organization
ameboidal-type cell migration
acrosome assembly
neuron migration
positive regulation of cytokine-mediated signaling pathway
microtubule-based process
mitotic nuclear division
nuclear migration
chemical synaptic transmission
neuroblast proliferation
brain development
learning or memory
retrograde axonal transport
adult locomotory behavior
protein secretion
negative regulation of neuron projection development
lipid catabolic process
cell migration
stem cell division
transmission of nerve impulse
corpus callosum morphogenesis
hippocampus development
layer formation in cerebral cortex
cerebral cortex neuron differentiation
cerebral cortex development
actin cytoskeleton organization
microtubule organizing center organization
osteoclast development
positive regulation of axon extension
positive regulation of mitotic cell cycle
negative regulation of JNK cascade
vesicle transport along microtubule
brain morphogenesis
neuromuscular process controlling balance
nuclear envelope disassembly
establishment of centrosome localization
lipid metabolic process
transport
cell cycle
multicellular organism development
nervous system development
cell differentiation
regulation of GTPase activity
cell division
G2/M transition of mitotic cell cycle
sister chromatid cohesion
germ cell development
positive regulation of embryonic development
establishment of planar polarity of embryonic epithelium
cortical microtubule organization
platelet activating factor metabolic process
auditory receptor cell development
positive regulation of dendritic spine morphogenesis
regulation of microtubule cytoskeleton organization
cochlea development
microtubule cytoskeleton organization involved in establishment of planar polarity
regulation of microtubule motor activity
phospholipase A2 activity
protein binding
microtubule binding
heparin binding
protein complex binding
dynactin binding
protein homodimerization activity
phospholipase binding
dynein binding
dynein intermediate chain binding
phosphoprotein binding
platelet-activating factor acetyltransferase activity
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