Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene.
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Protein Aliases: CMT1C; Eet-1; Estrogen-enhanced transcript protein; Estrogen-enhanced transcript protein 1; estrogen-responsive uterine transcript; FLJ38636; lipopolysaccharide-induced TNF factor; lipopolysaccharide-induced TNF-alpha factor; Lipopolysaccharide-induced tumor necrosis factor-alpha factor; Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog; LITAF-like protein; LPS-induced TN factor; LPS-induced TNF-alpha factor; LPS-induced TNF-alpha factor homolog; mEET; MGC116698; MGC116700; MGC116701; MGC125274; MGC125275; MGC125276; NEDD4 WW domain-binding protein 3; p53-induced gene 7 protein; PIG 7; Small integral membrane protein of lysosome/late endosome; tumor protein p53 inducible protein 7
Gene Aliases: 3222402J11Rik; C85531; EET-1; LITAF; N4WBP3; PIG7; SIMPLE; TBX1; TP53I7
Molecular Function: transcription factor