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Invitrogen
LKB1 Polyclonal Antibody
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FIGURE: 1 / 5
LKB1 Antibody (PA5-14072) in ICC/IF
Immunocytochemistry analysis of LKB1 in ZR-75-1 cells. Samples were incubated in LKB1 polyclonal antibody (Product # PA5-14072) followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red). DAPI was used to stain the cell nuclear (blue).
Product Details
PA5-14072
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 14-44 amino acids from the N-terminal region of human STK11 (LKB1)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
200 µg
Purification
Ammonium sulfate precipitation, Size-exclusion - Dialysis
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with chicken, mouse, rat and Xenopus based on sequence homology.
Target Information
LKB1 (also known as STK11 - Serine/threonine-protein kinase STK11), a member of the serine/threonine kinase family, is a tumor suppressor. LKB1 physically associates with p53 and regulates specific p53 dependent apoptosis pathways. LKB1 is present in both the cytoplasm and nucleus of living cells and translocates to mitochondria during apoptosis. LKB1 functions as a master upstream protein kinase, regulating AMPK related kinases as well as AMPK. Mutations in LKB1 gene are associated with Peutz Jeghers syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CAMK group; CAMKL family; Liver kinase B1; LKB 1; LKB-1; LKB1; LKB1(S); polarization-related protein LKB1; Renal carcinoma antigen NY-REN-19; serine/threonine kinase 11; STK11; serine/threonine-protein kinase 11; serine/threonine-protein kinase LKB1; Serine/threonine-protein kinase STK11; unnamed protein product
Gene Aliases: hLKB1; LKB1; PJS; STK11
UniProt ID: (Human) Q15831
Entrez Gene ID: (Human) 6794
regulation of cell growth
tissue homeostasis
vasculature development
protein phosphorylation
protein dephosphorylation
autophagy
apoptotic process
cellular response to DNA damage stimulus
signal transduction
spermatogenesis
axonogenesis
negative regulation of cell proliferation
response to ionizing radiation
positive regulation of autophagy
peptidyl-threonine phosphorylation
establishment of cell polarity
regulation of Wnt signaling pathway
cell differentiation
negative regulation of cell growth
positive regulation of transforming growth factor beta receptor signaling pathway
activation of protein kinase activity
protein localization to nucleus
glucose homeostasis
anoikis
positive thymic T cell selection
protein autophosphorylation
regulation of dendrite morphogenesis
positive regulation of axonogenesis
T cell receptor signaling pathway
Golgi localization
regulation of cell cycle
regulation of protein kinase B signaling
epithelial cell proliferation involved in prostate gland development
negative regulation of epithelial cell proliferation involved in prostate gland development
G1 to G0 transition
cellular response to UV-B
intrinsic apoptotic signaling pathway by p53 class mediator
negative regulation of canonical Wnt signaling pathway
dendrite extension
negative regulation of cold-induced thermogenesis
positive regulation of protein localization to nucleus
positive regulation of vesicle transport along microtubule
regulation of signal transduction by p53 class mediator
negative regulation of TORC1 signaling
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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