Immunogen sequence: RRHRGYLSET VSNALGPQGR RLEEVRLKPI LASAKQHSPV TEGAVEVKYE GHWRQVCDQG WTMN
Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 91%.
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.
Protein Aliases: FLJ21889; Lysyl oxidase homolog 4; lysyl oxidase related C; lysyl oxidase-like 4 pseudogene; Lysyl oxidase-like protein 4; Lysyl oxidase-related protein C
Gene Aliases: LOXC; LOXL4
UniProt ID: (Human) Q96JB6
Entrez Gene ID: (Human) 84171
Molecular Function: oxidase