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Invitrogen
LRP8 Polyclonal Antibody
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Product Details
PA1-16913
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Chicken,
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide made to a C-terminal portion of the human ApoER2 protein sequence (between residues 863-963).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
PA1-16913 is specific for the ~106 kDa (membrane form) ApoER2 protein.
A larger ~130 kDa band may also be seen (glycosylated form).
Suggested positive control: mouse brain membrane preparation.
Immunogen sequence homology: bovine (95%).
Target Information
Apolipoprotein E receptor 2 (ApoER2) is an NMDA associated protein found in neurons. It participates in important functions from guiding neurons in the embryonic brain to regulating synaptic signaling. It is also involved in debilitating neurodegenerative diseases such as schizophrenia and Alzheimer's disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ApoE receptor 2; Apolipoprotein E receptor 2; low density lipoprotein receptor relative, 8 ligand binding repeats, brain; low density lipoprotein receptor-related protein 8, apolipoprotein e receptor; Low-density lipoprotein receptor-related protein 8; LR8B; LRP-8; Protein LR8B
Gene Aliases: 4932703M08Rik; AA921429; AI848122; APOER2; HSZ75190; LR8B; LRP-8; LRP8; MCI1
UniProt ID: (Chicken) Q98931, (Human) Q14114
Entrez Gene ID: (Chicken) 396102, (Human) 7804, (Mouse) 16975
calcium ion binding
protein binding
transmembrane signaling receptor activity
low-density lipoprotein receptor activity
high-density lipoprotein particle binding
kinesin binding
very-low-density lipoprotein particle receptor activity
apolipoprotein binding
reelin receptor activity
glycoprotein binding
calcium-dependent protein binding
apolipoprotein
endocytosis
ventral spinal cord development
negative regulation of transcription from RNA polymerase II promoter
retinoid metabolic process
proteolysis
lipid metabolic process
receptor-mediated endocytosis
signal transduction
cytokine-mediated signaling pathway
ammon gyrus development
cerebral cortex development
positive regulation of CREB transcription factor activity
reelin-mediated signaling pathway
response to drug
positive regulation of peptidyl-tyrosine phosphorylation
modulation of synaptic transmission
positive regulation of dendritic spine morphogenesis
positive regulation of protein tyrosine kinase activity
cellular response to growth factor stimulus
cellular response to cholesterol
positive regulation of dendrite development
hippocampus development
layer formation in cerebral cortex
positive regulation of protein kinase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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