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Invitrogen
LRRC4 Polyclonal Antibody
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FIGURE: 1 / 1
LRRC4 Antibody (PA5-87809) in WB
Western blot analysis of LRRC4 in extracts of various cell lines. Samples were incubated with LRRC4 Polyclonal antibody (Product # PA5-87809) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.
Product Details
PA5-87809
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 544-653 of human LRRC4 (NP_0714261)
Conjugate
Form
Liquid
Concentration
2.07 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LIVFYKLRKR HQQRSTVTAA RTVEIIQVDE DIPAATSAAA TAAPSGVSGE GAVVLPTIHD HINYNTYKPA HGAHWTENSL GNSLHPTVTT ISEPYIIQTH TKDKVQETQI; Positive Samples: U-87MG, U-251MG, K-562, Mouse brain, Mouse liver, Rat brain, Rat liver; Cellular Location: Cell junction, Membrane, Single-pass type I membrane protein, postsynaptic cell membrane, synapse
Target Information
The LRRC4 gene, also known as netrin-G ligand 2 (NGL-2), is a brain-specific member of the leucine-rich repeat superfamily, playing a critical role in the central nervous system. Its expression is particularly high in areas such as the hippocampal CA1 and CA2 regions, as well as in granule cells of the dentate gyrus. LRRC4 is a known tumor suppressor gene associated with glioma suppression, as it regulates glioma cell growth, angiogenesis, and invasion through extensive signaling networks. It can participate in multiphase loops involving miRNA, transcription factors, and gene methylation modifications. This gene targets various genes involved in cell motility, impacting glioblastoma cell movement and polarization by binding to enhancer elements and activating transcription, notably the RAP1GAP gene. Its function and expression are crucial in maintaining normal brain function and hold potential implications in the management of gliomagenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: brain tumor associated protein LRRC4; Brain tumor-associated protein BAG; Brain tumor-associated protein MBAG1; leucine rich repeat containing 4 protein; leucine-rich repeat-containing 4; Leucine-rich repeat-containing protein 4; LIBG-like protein; LRRC4-like protein; Nasopharyngeal carcinoma-associated gene 14 protein; Netrin-G2 ligand; NGL-2; NLG2; protein NGL-2
Gene Aliases: BAG; LRRC4; MBAG1; NAG14; NGL-2; NLG-2; UNQ554/PRO1111
UniProt ID: (Human) Q9HBW1, (Mouse) Q99PH1, (Rat) Q45R42
Entrez Gene ID: (Human) 64101, (Mouse) 192198, (Rat) 641521
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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