Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
FIGURE: 1 / 2
LRRK1 Antibody (H00079705-B01P) in WB
Western Blot analysis of LRRK1 expression in transfected 293T cell line (H00079705-T01) by LRRK1 MaxPab polyclonal antibody.
Lane1:LRRK1 transfected lysate(28.71 KDa).
Lane2:Non-transfected lysate.
Lane1:LRRK1 transfected lysate(28.71 KDa).
Lane2:Non-transfected lysate.
Product Details
H00079705-B01P
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
LRRK1 (AAH68080.1, 1 a.a. approximately 261 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MSQRPPSMYW CVGPEESAVC PERAMETLNG AGDTGGKPST RGGDPAARSR RTEGIRAAYR RGDRGGARDL LEEACDQCAS QLEKGQLLSI PAAYGDLEMV RYLLSKRLVE LPTEPTDDNP AVVAAYFGHT AVVQELLESL PGPCSPQRLL NWMLALACQR GHLGVVKLLV LTHGADPESY AVRKNEFPVI VRLPLYAAIK SGNEDIAIFL LRHGAYFCSY ILLDSPDPSK HLLRKYFIEA SPLPSSYPGK TVSSHCLWSV F
Target Information
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: leucine-rich repeat kinase 1; Leucine-rich repeat serine/threonine-protein kinase 1; LRRK1
Gene Aliases: KIAA1790; LRRK1; RIPK6; Roco1
UniProt ID: (Human) Q9H5S3
Entrez Gene ID: (Human) 79705, (Rat) 308703
protein phosphorylation
small GTPase mediated signal transduction
osteoclast development
bone resorption
positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of peptidyl-tyrosine phosphorylation
positive regulation of canonical Wnt signaling pathway
positive regulation of intracellular signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support