PA1-18254 detects LRRK2 from human samples.
PA1-18254 has been successfully used in immunohistochemistry (paraffin and frozen) procedures.
The PA1-18254 immunogen is a synthetic peptide corresponding to residues (L(946) K R K R K I L S S D D S L R S S(962) of human LRRK2 protein, conjugated to Blue Carrier Protein.
Reconstitute with 100 µL of distilled water.
This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: augmented in rheumatoid arthritis 17; BC 300-268; Dardarin; DKFZp434H2111; FLJ45829; leucine-rich repeat kinase 2; Leucine-rich repeat serine/threonine-protein kinase 2; LRR kinase 2; LRRK 2; LRRK-2
Gene Aliases: AURA17; DARDARIN; LRRK2; PARK8; RIPK7; ROCO2
UniProt ID: (Human) Q5S007