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Proteintech
LRWD1 Polyclonal Antibody
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Product Details
19546-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
0.35 mg/mL
Amount
52.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
The antibody recognizes the N-term of LRWD1.
Target Information
Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CENP-33; Centromere protein 33; Leucine-rich repeat and WD repeat-containing protein 1; ORC-associated protein; ORCA; Origin recognition complex-associated protein; testicular tissue protein Li 4; unnamed protein product
Gene Aliases: 1200011O22Rik; AU042569; AW548074; CENP-33; LRWD1; ORCA
UniProt ID: (Human) Q9UFC0, (Mouse) Q8BUI3
Entrez Gene ID: (Rat) 304396, (Human) 222229, (Mouse) 71735
chromatin organization
transcription, DNA-templated
protein phosphorylation
cell proliferation
cytokine-mediated signaling pathway
positive regulation of transcription from RNA polymerase II promoter
establishment of protein localization to chromatin
DNA replication
DNA replication initiation
chromatin modification
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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