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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant protein fragment corresponding to a region within amino acids 1 and 243 of Human LXR alpha|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:1000-1:10,000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-29868 targets LXR alpha in WB applications and shows reactivity with Human samples.
The PA5-29868 immunogen is recombinant protein fragment corresponding to a region within amino acids 1 and 243 of Human LXR alpha.
The liver X receptors, LXRA and LXRB (NR1H2; MIM 600380), form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
liver X nuclear receptor alpha variant 1; Liver X receptor alpha; LXR-a; LXRA; Nuclear receptor subfamily 1 group H member 3; nuclear receptor subfamily 1, group H, member 3; Oxysterols receptor LXR-alpha; RLD-1
LXR-a; LXRA; NR1H3; RLD-1