NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor that exhibits a ligand-dependent transcriptional activiation activity. Its interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides. NR1H3 plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiqutination of LDLR, VLDLR, and LRP8. It also interplays functionally with RORA for the regulation of genes involves in liver metabolism.
Protein Aliases: liver X nuclear receptor alpha variant 1; liver X nuclear receptor beta; Liver X Receptor; Liver X receptor alpha; Liver X receptor beta; LX receptor beta; LXR alpha; LXR beta; nuclear orphan receptor LXR-alpha; nuclear orphan receptor LXR-beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; Nuclear receptor subfamily 1 group H member 3; nuclear receptor subfamily 1, group H, member 2; nuclear receptor subfamily 1, group H, member 3; Orphan nuclear receptor OR-1; Oxysterols receptor LXR-alpha; Oxysterols receptor LXR-beta; Retinoid X receptor-interacting protein No.15; RLD-1; steroid hormone-nuclear receptor NER; ubiquitous receptor; Ubiquitously-expressed nuclear receptor; ubiquitously-expressed nuclear receptor 1; ubiquitously-expressed nuclear receptor 2; UR
Gene Aliases: AI194859; AU018371; LXR; LXR-a; LXR-b; LXRA; LXRalpha; LXRB; LXRbeta; NER; NER-I; NER1; NR1H2; NR1H3; OR-1; RIP15; RLD-1; RLD1; UNR; Unr1; Unr2; UR