Immunogen sequence: FLPEGGCYEL LTVIGKGFED LMTVNLARYK PTGEYVTVRR INLEACSNEM VTFLQGELHV SKLFNHPNIV PYRATFIADN ELWVVTSFMA YGSAKDLICT HFMDGMNELA IAYILQGVLK ALDYIHHMGY VHRSVKASHI LISVDGKVYL SGLRSNLSMI SHGQRQRVVH DFPKYSVKVL PWLSPE; Positive Samples: Mouse skeletal muscle; Cellular Location: Cytoplasm, Nucleus
LYK5; STE20-related Adaptor Protein (STRAD); FLJ90524. Gene Map Locus is 17q23.3 and members of STE-20 like kinase family are known to stimulate MAPK pathways by directly activating MAPKKK. STRAD is a novel pseudokinase member of this family consisting of a STE-20 like kinase domain but lacks several residues that are required for its catalytic activity. It specifically binds LKB1 and plays a key role in regulating tumor suppressor activities of LKB1. It functions as an upstream activator of LKB1 and also directs the sub-cellular localization of LKB1 by anchoring it in the cytoplasm. STRAD-LKB1 interaction results in phosphorylation of STRAD and enhanced autophosphorylation of LKB1.
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Protein Aliases: protein kinase LYK5; Serologically defined breast cancer antigen NY-BR-96; STE20-like pseudokinase; STE20-related adapter protein; STE20-related kinase adapter protein alpha; STRAD alpha
Gene Aliases: 2610019A05Rik; 6030402H20Rik; AI480680; E130112C09Rik; LYK5; NY-BR-96; PMSE; Stlk; STRAD; STRADA
Molecular Function: non-receptor serine/threonine protein kinase