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Invitrogen

LYPLA3 Polyclonal Antibody

Advanced Verification

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details

View all (6) LYPLA3 antibodies
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Product Details

Applications
Tested Dilution
Publications
Immunohistochemistry (IHC)
1:50-1:200
-
Western Blot (WB)
0.04-0.4 µg/mL
-
Product Specifications
Species Reactivity
Human, Mouse, Rat
Host / Isotype
Rabbit / IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human LYPLA3
Conjugate
Unconjugated
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
AB_2643631

Product Specific Information

Immunogen sequence: GVAKTLRVLA SGDNNRIPVI GPLKIREQQR SAVSTSWLLP YNYTWSPEKV FVQTPTINYT LRDYRKFFQD IGFED

Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 92%.

Target Information

Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free fatty acid. This enzyme is present in the plasma and thought to be associated with high-density lipoprotein. A later paper contradicts the function of this gene. It demonstrates that this gene encodes a lysosomal enzyme instead of a lysophospholipase and has both calcium-independent phospholipase A2 and transacylase activities.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 1-O-acylceramide synthase; 1-O-acylceramide synthase {ECO:0000303|PubMed:15294901}; ACS; ACS {ECO:0000303|PubMed:15294901}; Group XV phospholipase A2; group XV phospholipase A2 {ECO:0000312|EMBL:AAH98894.1}; LCAT-like lysophospholipase; LCAT-like lysophospholipase {ECO:0000250|UniProtKB:Q8VEB4}; LLPL; LLPL {ECO:0000250|UniProtKB:Q8VEB4}; LPLA2; LPLA2 {ECO:0000303|PubMed:15294901}; Lysophospholipase 3; lysophospholipase 3 (lysosomal phospholipase A2); lysophospholipase 3 {ECO:0000250|UniProtKB:Q8VEB4}; Lysosomal phospholipase A2; lysosomal phospholipase A2 {ECO:0000303|PubMed:15294901, ECO:0000312|EMBL:AAS66767.1}; phospholipase A2, group XV; pla2g15 {ECO:0000312|Ensembl:ENSRNOP00000026996, ECO:0000312|RGD:1302982}

Gene Aliases: 1-O-acylceramidesynthase; ACS; C87498; GXVPLA2; LLPL; LPLA2; LYPLA3; PLA2G15; UNQ341/PRO540

UniProt ID: (Human) Q8NCC3, (Mouse) Q8VEB4, (Rat) Q675A5

Entrez Gene ID: (Human) 23659, (Mouse) 192654, (Rat) 361401

Molecular Function: acyltransferase hydrolase lipase phospholipase transferase

Function(s)
glycerophospholipid metabolic process ceramide metabolic process fatty acid catabolic process phosphatidylcholine catabolic process phosphatidylethanolamine catabolic process lipid metabolic process fatty acid metabolic process phosphatidylcholine metabolic process
Process(es)
lysophospholipase activity phospholipid binding O-acyltransferase activity calcium-independent phospholipase A2 activity dihydrolipoamide branched chain acyltransferase activity sterol O-acyltransferase activity N-acetyltransferase activity palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity carnitine O-acyltransferase activity acetyltransferase activity C-acyltransferase activity palmitoyltransferase activity N-acyltransferase activity acylglycerol O-acyltransferase activity serine O-acyltransferase activity O-acetyltransferase activity O-octanoyltransferase activity octanoyltransferase activity O-palmitoyltransferase activity S-acyltransferase activity S-acetyltransferase activity S-malonyltransferase activity malonyltransferase activity C-palmitoyltransferase activity transferase activity transferase activity, transferring acyl groups succinyltransferase activity N-succinyltransferase activity O-succinyltransferase activity S-succinyltransferase activity sinapoyltransferase activity O-sinapoyltransferase activity hydrolase activity peptidyl-lysine N6-myristoyltransferase activity peptidyl-lysine N6-palmitoyltransferase activity benzoyl acetate-CoA thiolase activity 3-hydroxybutyryl-CoA thiolase activity 3-ketopimelyl-CoA thiolase activity N-palmitoyltransferase activity myristoyltransferase activity acyl-CoA N-acyltransferase activity protein-cysteine S-myristoyltransferase activity protein-cysteine S-acyltransferase activity dihydrolipoamide S-acyltransferase activity glucosaminyl-phosphotidylinositol O-acyltransferase activity ergosterol O-acyltransferase activity lanosterol O-acyltransferase activity naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity 2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity 2-methylhexanoyl-CoA C-acetyltransferase activity butyryl-CoA 2-C-propionyltransferase activity 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity L-2-aminoadipate N-acetyltransferase activity UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase activity keto acid formate lyase activity Ras palmitoyltransferase activity azetidine-2-carboxylic acid acetyltransferase activity peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor acetyl-CoA:L-lysine N6-acetyltransferase

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