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Invitrogen
LZTFL1 Polyclonal Antibody
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Product Details
PA5-60370
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human LZTFL1. Recombinant protein control fragment (Product #RP-100204).
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Amount
40 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: NTAYTNVLLL RQLFAQAEKW YLKLQTDISE LENRELLEQV AEFEKAEITS SNKKPILDVT KPKLAPLNEG GTAELLN
Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 87%.
Target Information
LZTFL1, also known as Leucine Zipper Transcription Factor-Like 1, is situated on the chromosomal region 3p21.3, which is frequently deleted in various cancers, including kidney cancer. It acts as a tumor suppressor by destabilizing AKT, a key protein in cell growth pathways, thus inhibiting tumor cell growth. Additionally, LZTFL1 has been implicated in the epithelial-mesenchymal transition in COVID-19, suggesting a role in viral response pathways. It is associated with Bardet-Biedl syndrome (BBS) and interacts with IFT27, a regulator of sperm flagellum formation, affecting spermatogenesis and male fertility. Knockout models show a phenotype of obesity, retinal degeneration, and abnormal cilia development, highlighting its role in normal ciliary function. The gene has two transcript isoforms and is part of a transcriptional map covering 250 kb, making it a subject of extensive genetic research.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Leucine zipper transcription factor-like protein 1; unnamed protein product
Gene Aliases: BBS17; LZTFL1
UniProt ID: (Human) Q9NQ48
Entrez Gene ID: (Human) 54585
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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