Immunogen sequence: MGPKDSAKCL HRGPQPSHWA AGDGPTQERC GPRSLGSPVL GLDTCRAWDH VDGQILGQLR PLTEEEEEEG AGATLSRGPA FPGMGSEELR LASFYDWPLT AEVPPELLAA AGFFHTGHQD KVRCFFCYGG LQSWKRGDDP WTEHAKWFPS CQFLLRSKGR DFVHSVQETH SQLLGSWDPW EEPEDAAPVA PSVPASGYPE LPTPRREVQS ESAQEPGGVS PAEAQRAWWV LEPPGARDVE AQLRRLQEER TCKVCLDRAV SIVFV; Positive Samples: Mouse liver, Mouse skeletal muscle; Cellular Location: Cytoplasm, Golgi apparatus, Nucleus
The inhibitor of apoptosis (IAP) family of proteins regulates programmed cell death triggered by various stimuli. All IAPs have at least one baculovirus IAP repeat (BIR) motif that is essential for their anti-apoptotic activity. Recently, it has been identified that a novel human inhibitor of apoptosis protein (IAP) family member termed Livin or ML-IAP, which contains a single baculoviral IAP repeat (BIR) domain and a COOH-terminal RING finger domain. Livin gene has two splicing variants that contain open reading frames of 298 and 280 amino acids and both contained a single copy of baculovirus IAP repeat (BIR) and RING domain. Both of the isoforms inhibit TNFa induced apoptosis in Jurkat cells. Livin expression is low in adult tissues. It is relatively expressed at a higher level in developmental tissues and in many cancer cells.
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Protein Aliases: baculoviral IAP repeat-containing 7; baculoviral IAP repeat-containing 7 (livin); Baculoviral IAP repeat-containing protein 7; Baculoviral IAP repeat-containing protein 7 30 kDa subunit; Baculoviral IAP repeat-containing protein 7 30kDa subunit; KIAP; Kidney inhibitor of apoptosis protein; Livin; livin inhibitor of apoptosis; Melanoma inhibitor of apoptosis protein; ML-IAP; RING finger protein 50; RING-type E3 ubiquitin transferase BIRC7; Truncated livin
Gene Aliases: BIRC7; E130019N06; KIAP; LIVIN; ML-IAP; MLIAP; RGD1562883; RNF50; UNQ5800/PRO19607/PRO21344