For immunofluorescence on yeast cells, try MCA-39C7 diluted 1:100 to 1:500. For immunofluorescence on mammalian cells try at 1:50 to 1:100.
The nuclear pore complex (NPC) is a protein assembly localized at the nuclear rim and mediates macromolecular transport between the nucleus and the cytoplasm. The mammalian nucleoporin (NUP)-107 is part of the hetero-oligomeric complex that also contains NUP160, NUP133, NUP96, and mammalian homolog of yeast sec13p. While the majority of the NUP107-160 nuclear pore sub-complex localizes to the nuclear pore, a small fraction is observed at kinetochores and pro-metaphase spindle poles in mitotic cells in association with proteins such as Mad1, Mad2, Bub3 and Cdc20. Immunodepletion of the NUP107-160 complex resulted in defective spindle assembly indicating that it has multiple functions. NUP107 has recently been identified as an HIV dependency factor (HDF), suggesting that NUP107 may be an important drug target in HIV treatment. Multiple isoforms of NUP107 are known to exist.
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Protein Aliases: 107 kDa nucleoporin; CG6743-PA; nuclear pore complex; Nuclear pore complex protein Nup107; nucleoporin 107; nucleoporin 107kD; nucleoporin 107kDa; Nucleoporin Nup107; Nup107-PA; Nup170; p105
Gene Aliases: AW541137; BcDNA:LD18761; C76801; CG6743; Dmel\CG6743; Dmel_CG6743; dmNup107; NPHS11; Nup 107; NUP107; Nup170; NUP84
Molecular Function: transporter