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Invitrogen

HLA-DR/DP Monoclonal Antibody (MEM-136)

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HLA-DR/DP Monoclonal Antibody (MEM-136)

Product Details

MA1-19227

Applications
Tested Dilution
Publications

Western Blot (WB)

1 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-

Flow Cytometry (Flow)

1-4 µg/mL
-

Immunoprecipitation (IP)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

MEM-136

Immunogen

PHA-activated peripheral blood lymphocytes.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

15mM sodium azide

Storage conditions

4°C, do not freeze

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1076780

Product Specific Information

This antibody reacts with alpha/beta dimer as well as with dissociated beta-subunit. DR and DP are the isotypes of human MHC Class II molecules expressed on antigen-presenting cells (APC; dendritic cells, B lymphocytes, monocytes, macrophages).

Target Information

HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Jul 2008].

HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: cell surface glycoprotein; integral membrane protein; class II HLA histocompatibility antigen; DP beta 1 domain protein; DRB52; HLA class II histocompatibility antigen, DP beta 1 chain; HLA class II histocompatibility antigen, DP(W4) beta chain; HLA class II histocompatibility antigen, DR-1 beta chain; HLA class II histocompatibility antigen, DRB1 beta chain; HLA DP4 beta-chain; HLA-D; HLA-DP histocompatibility type, beta-1 subunit; HLA-DR; HLA-DR-beta chain; HLA-DRB1; human leucocyte antigen DRB1; Human leukocyte antigen DRB1; light chain; lymphocyte antigen DRB1; MHC Class 2; MHC class II; MHC class II antigen DPB1; MHC class II HLA-DP-beta-1; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DR4 protein; MHC DR beta protein precursor; MHC DR-beta; MHC DR7-beta-2 chain; MHC HLA DPB1; MHC HLA DR5 cell surface glycoprotein beta chain precursor; MHC HLA-D; MHC HLA-DPw4b-beta chain precursor; MHC HLA-DR-beta chain precursor; MHC HLA-DR-beta chain precursor old gene name 'HLA-DRA1'; MHC HLA-DR-beta-1 chain; MHC HLA-DR-beta-2 precursor; MHC HLA-DR1-beta; MHC HLA-DR2 (non-Dw2/non-Dw12)b glycoprotein beta-chain; MHC HLA-DR2(Dw12)b glycoprotein beta-chain; MHC HLA-DR2(Dw2)b glycoprotein beta-chain; MHC HLA-DRw10-beta-2 protein precursor; MHC HLA-SB-beta chain I; MHC II HLA; SB-beta chain; unnamed protein product

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Gene Aliases: DPB1; DRB1; HLA-DP; HLA-DP1B; HLA-DPB; HLA-DPB1; HLA-DR1B; HLA-DRB; HLA-DRB1; SS1

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UniProt ID: (Human) P79608, (Human) P01911

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Entrez Gene ID: (Human) 3115, (Human) 3123

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Function(s)
protein binding MHC class II protein complex binding peptide antigen binding structural constituent of cytoskeleton polysaccharide binding MHC class II receptor activity T cell receptor binding CD4 receptor binding
Process(es)
adaptive immune response immune system process peptide antigen assembly with MHC class II protein complex antigen processing and presentation of peptide or polysaccharide antigen via MHC class II immune response antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II positive regulation of interferon-gamma production positive regulation of T cell proliferation positive regulation of immune response T cell receptor signaling pathway positive regulation of T cell activation positive regulation of T cell mediated cytotoxicity positive regulation of protein phosphorylation inflammatory response to antigenic stimulus myeloid dendritic cell antigen processing and presentation antigen processing and presentation of endogenous peptide antigen via MHC class II positive regulation of T cell mediated immune response to tumor cell negative regulation of inflammatory response to antigenic stimulus humoral immune response cytoskeleton organization signal transduction epidermis development detection of bacterium macrophage differentiation regulation of interleukin-10 production regulation of interleukin-4 production negative regulation of interferon-gamma production positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation positive regulation of kinase activity positive regulation of insulin secretion involved in cellular response to glucose stimulus T-helper 1 type immune response negative regulation of T cell proliferation positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of memory T cell differentiation positive regulation of MAPK cascade regulation of T-helper cell differentiation positive regulation of monocyte differentiation positive regulation of transcription, DNA-templated positive regulation of viral entry into host cell protein tetramerization positive regulation of ERK1 and ERK2 cascade positive regulation of CD4-positive, alpha-beta T cell activation
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