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Invitrogen
Transferrin Receptor Monoclonal Antibody (MEM-75), PE
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FIGURE: 1 / 3
Transferrin Receptor Antibody (MA1-19640) in Flow
Flow cytometry surface staining of Transferrin Receptor in PHA stimulated lymphocytes. Samples were stained with Transferrin Receptor PE monoclonal antibody (Product # MA1-19640) using a dilution of 1.67 μg/mL (red-filled). Cells were separated from PHA stimulated lymphocytes stained using mouse IgG1 isotype control (MOPC-21) PE antibody (concentration in sample 1.67 μg/mL, same as CD71 PE concentration, bl... View More
Product Details
MA1-19640
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
MEM-75
Immunogen
Pre-B cell line NALM-6.
Conjugate
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Concentration
0.055 mg/mL
Purification
Size-exclusion chromatography
Storage buffer
PBS, pH 7.4, with 0.2% BSA
Contains
15mM sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody reacts with an extracellular epitope of CD71 antigen (transferrin receptor), a 95 kDa type II homodimeric transmembrane glycoprotein expressed on activated B and T lymphocytes, macrophages and erythroid precursors; it is lost on resting blood leukocytes.
The antibody MEM-75 does not block binding of transferrin to the receptor.
Target Information
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD antigen CD71; CD71; p90; T9; TR; Transferrin receptor protein 1
Gene Aliases: CD71; IMD46; p90; T9; TFR; TFR1; TFRC; TR; TRFR
UniProt ID: (Human) P02786
Entrez Gene ID: (Human) 7037
virus receptor activity
glycoprotein binding
double-stranded RNA binding
transferrin receptor activity
protein binding
Hsp70 protein binding
transferrin transmembrane transporter activity
identical protein binding
protein homodimerization activity
poly(A) RNA binding
chaperone binding
metalloprotease
regulation of cell growth
response to hypoxia
cellular iron ion homeostasis
acute-phase response
aging
response to nutrient
response to iron ion
response to manganese ion
osteoclast differentiation
positive regulation of B cell proliferation
receptor internalization
response to retinoic acid
transferrin transport
cellular response to drug
positive regulation of T cell proliferation
regulation of cell proliferation
positive regulation of bone resorption
positive regulation of isotype switching
response to copper ion
viral entry into host cell
iron ion import
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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