Search
Invitrogen
ITGA2 Monoclonal Antibody (AK7), Biotin
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
MA1-80244
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Non-human primate
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
AK7
Immunogen
Proprietary Immunogen.
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS with 1% BSA
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL.
Mouse anti Human CD49b antibody, clone AK7 recognizes the integrin alpha 2 subunit, a approximately 160 kDa glycoprotein that non-covalently associates with the approximately 130 kDa integrin beta 1 subunit to form the VLA-2 complex.
Target Information
CD49b (Integrin alpha 2, Integrin alpha 2 chain, VLA-2 alpha chain, HM alpha 2) is a member of the integrin family. It is a glycoprotein with molecular weight of 150 kD, and it complexes with CD29 (Integrin beta 1) to form the heterodimeric integrin VLA-2 (integrin alpha 2 beta 1, or GPIa/IIa) complex. VLA-2 is an extracellular receptor for laminin, collagen, and fibronectin, and interaction with its ligands results in the activation of intracellular signaling pathways. It has reported roles in VEGF-induced angiogenesis in vivo, as well as adhesion and lymphocyte activation. CD49b is expressed by NK cells, NK-T cells, monocytes, platelets, and epithelial cells. It is also expressed on adaptive immune cells such as T and B cells, specifically on a subset of CD4+ T cells in the spleen, on intraepithelial and lamina propria lymphocytes in the intestine, as well as on a population of peripheral CD4+ type 1 T regulatory (Tr1) cells that co-express LAG-3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alpha 2 integrin; alpha 2 subunit of VLA-2 receptor; BDPLT9; CD49 antigen-like family member B; CD49b; Collagen receptor; glycoprotein Ia; GPIa; human platelet alloantigen 5; human platelet alloantigen system 5; Integrin alpha-2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); platelet antigen Br; platelet glycoprotein GPIa; Platelet membrane glycoprotein Ia; unnamed protein product; very late activation protein 2 receptor, alpha-2 subunit; very late activation receptor alpha-2 subunit; very late activation receptor subunit alpha-2; VLA-2 subunit alpha; VLA2 receptor
Gene Aliases: BR; CD49B; GPIa; HPA-5; ITGA2; VLA-2; VLAA2
UniProt ID: (Human) P17301
Entrez Gene ID: (Human) 3673
beta-amyloid binding
virus receptor activity
integrin binding
protein binding
collagen binding
signaling receptor activity
collagen receptor activity
laminin binding
heparan sulfate proteoglycan binding
macromolecular complex binding
metal ion binding
collagen binding involved in cell-matrix adhesion
response to hypoxia
positive regulation of leukocyte migration
substrate-dependent cell migration
hypotonic response
cell adhesion
cell-matrix adhesion
integrin-mediated signaling pathway
female pregnancy
blood coagulation
response to xenobiotic stimulus
organ morphogenesis
positive regulation of epithelial cell migration
response to amine
response to muscle activity
positive regulation of smooth muscle cell migration
extracellular matrix organization
mammary gland development
positive regulation of cell projection organization
cell-substrate adhesion
positive regulation of collagen biosynthetic process
response to L-ascorbic acid
cell adhesion mediated by integrin
collagen-activated signaling pathway
skin morphogenesis
positive regulation of translation
positive regulation of cell adhesion
positive regulation of smooth muscle contraction
viral entry into host cell
focal adhesion assembly
mesodermal cell differentiation
positive regulation of smooth muscle cell proliferation
positive regulation of positive chemotaxis
detection of mechanical stimulus involved in sensory perception of pain
positive regulation of transmission of nerve impulse
positive regulation of phagocytosis, engulfment
hepatocyte differentiation
response to parathyroid hormone
cellular response to mechanical stimulus
cellular response to estradiol stimulus
cell-cell adhesion
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support