MA1-826 detects C/EBP beta protein in human, mouse, and rat samples. MA1-826 only detects the LAP* isoform of C/EBP beta.
MA1-826 has successfully been used in Western blot, immunofluorescent and immunoprecipitation procedures. By Western blot, this antibody detects a 37 kDa protein representing LAP* of C/EBP beta (N-terminus fragment) in transfected 293T cells.
The MA1-826 immunogen is a synthetic peptide corresponding to residues M(1) H R L L A W D A A C L P P P A A F P K L H(21) of mouse C/EBP beta. This peptide (Cat. # PEP-243) is available for use in neutralization and control experiments.
The C/EBP (CCAAT/enhancer binding protein) family of transcription factors--alpha, beta, delta, and epsilon)--are widely expressed proteins found in a variety of tissues. These domains contain an evolutionarily conserved five-amino acid motif (the regulatory domain motif RDM) that conforms to the consensus sequence (I/V/L) KXEP. One of the major roles of these transcription factors is that of metabolic regulation in liver and fat cells. Studies suggest that these transcription factors act in a cascade aiding in the development of the adipose cell. Three C/EBP beta isoforms (LAP*, LAP, and LIP) arise from different translation initiation and display different function in gene regulation. From a neurological standpoint, C/EBPs have been implicated in the mediation of nerve growth factor, altering synaptic plasticity, and mediation of inflammatory response in AD patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: AGP/EBP; C/EBP BETA; C/EBP-related protein 2; CCAAT/enhancer binding protein (C/EBP), beta; CCAAT/Enhancer Binding Protein Beta; CCAAT/enhancer-binding protein beta; IL-6DBP; interleukin 6-dependent DNA-binding protein; Interleukin-6-dependent-binding protein; LAP; LIP; Liver activator protein; Liver-enriched inhibitory protein; Liver-enriched transcriptional activator; Nuclear factor NF-IL6; nuclear factor of interleukin 6; nuclear factor-IL6; nuclear protein Il6; SF-B; Silencer factor B; TCF-5; Transcription factor 5; transcription factor C/EBP beta
Gene Aliases: C/EBP-beta; C/EBPbeta; CEBPB; CRP2; IL-6DBP; IL6DBP; LAP; LIP; NF-IL6; NF-M; Nfil6; PP9092; Sfb; TCF5