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Invitrogen
TGM2 Monoclonal Antibody (CUB 7402), Biotin
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FIGURE: 1 / 9
TGM2 Antibody (MA5-12736) in WB
Western blot analysis was performed on whole cell extracts (30 µg lysate) of HeLa (Lane 1), MDA-MB-231 (Lane 2), K-562 (Lane 3) and A549 (Lane 4). The blots were probed with Mouse anti-TGM2 Monoclonal Antibody (Product # MA5-12736, 2 µg/mL) and detected by chemiluminescence using Goat anti-Mouse IgG (H+L) Superclonal™ Secondary Antibody, HRP conjugate (Product # A28177, 0.25 µg/mL, 1:4000 dilution). A 78 kDa band corresponding to TGM2 was observed across the cell lines tested. Known quantity of protein samples were electrophoresed using No... View More
Product Details
MA5-12736
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Guinea pig,
Human,
Rabbit
Published species
Dog,
Hamster,
Human,
Mouse,
Non-human primate,
Pig,
Rat
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
CUB 7402
Immunogen
Purified guinea pig liver TGase II
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 0.2% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-12736 targets Transglutaminase II in IF, IHC (P), IP, and WB applications and shows reactivity with Canine, Guinea Pig, Human, and Rabbit samples.
The MA5-12736 immunogen is purified guinea pig liver TGase II.
Target Information
Transglutaminase (TGase) catalyses the crosslink of proteins by forming e-(g-glutamyl) lysine isopeptide bonds and requires the binding of Ca2+ for its activity. In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase), also known as TGase 2, has four distinct domains: N-terminal b-sandwich, catalytic core and two C-terminal b-barrel domains. tTGase may have a role in cell death, cell proliferation, cell differentiation, and receptor-mediated endocytosis. In the Alzheimer's disease brain, the elevated tTGase activity is manifested by polymerization of a number of proteins, including Ab peptide, b-amyloid precursor protein and the tau protein, with formation of neurofibrillary tangles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: C polypeptide, protein-glutamine-gamma-glutamyltransferase; crosslinker; Erythrocyte transglutaminase; G alpha h; G(h); G-ALPHA-h; GNAH; Heart G alpha(h); hhG alpha(h); Isopeptidase TGM2; Protein G alpha(h); Protein-glutamine deamidase TGM2; Protein-glutamine dopaminyltransferase TGM2; Protein-glutamine gamma-glutamyltransferase 2; Protein-glutamine histaminyltransferase TGM2; Protein-glutamine noradrenalinyltransferase TGM2; Protein-glutamine serotonyltransferase TGM2; RP5-1054A22.2; TG(C); TG2; TGase C; TGase H; TGase II; TGase-2; TGase-H; Tissue transglutaminase; Tissue type transglutaminase; transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase); Transglutaminase 2 C polypeptide; transglutaminase 2, C polypeptide; Transglutaminase C; Transglutaminase H; Transglutaminase II; Transglutaminase-2; tTG; tTgase; unnamed protein product
Gene Aliases: G(h); hTG2; TG(C); TGC; TGM2; tTG
UniProt ID: (Human) P21980
Entrez Gene ID: (Human) 7052, (Dog) 485867, (Rabbit) 100352148, (Guinea pig) 100379228
nucleotide binding
protein-glutamine gamma-glutamyltransferase activity
calcium ion binding
protein binding
GTP binding
peptidase activity
transferase activity
transferase activity, transferring acyl groups
hydrolase activity
metal ion binding
protein-glutamine glutaminase activity
peptide serotonyltransferase activity
histone serotonyltransferase activity
peptide dopaminyltransferase activity
histone dopaminyltransferase activity
peptide noradrenalinyltransferase activity
peptide histaminyltransferase activity
transferase
chromatin remodeling
proteolysis
phospholipase C-activating G-protein coupled receptor signaling pathway
gene expression
dopamine secretion
peptide cross-linking
protein deamination
negative regulation of endoplasmic reticulum calcium ion concentration
regulation of apoptotic process
positive regulation of apoptotic process
apoptotic cell clearance
positive regulation of GTPase activity
positive regulation of cell adhesion
positive regulation of neurogenesis
positive regulation of small GTPase mediated signal transduction
protein homooligomerization
positive regulation of mitochondrial calcium ion concentration
bone development
branching involved in salivary gland morphogenesis
salivary gland cavitation
cellular response to cocaine
cellular response to dopamine
positive regulation of sprouting angiogenesis
cellular response to serotonin
regulation of apoptotic cell clearance
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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