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Invitrogen
CD137 Monoclonal Antibody (BBK-2), Biotin
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FIGURE: 1 / 2
CD137 Antibody (MA5-13736) in Flow
Flow cytometry analysis of CD137 in PBMC cells stimulated with PHA for 3 days (green) compared to an isotype control (blue). Human blood was collected, combined with a hydrophilic polysaccharide, centrifuged, transferred to a conical tube and washed with PBS. 50 µL of cell solution was added to each tube at a dilution of 2x10^7 cells/mL, followed by the addition of 50 µL of isotype control and primary antibody (Product # MA5-13739) at a dilution of 1 µg/test. Cells were incubated for 30 min at 4°C and washed with a cell buffer, followed by... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-13736
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
BBK-2
Immunogen
Ectodomain of human 4-1BB recombinant protein
Conjugate
Biotin
Biotin
Biotin
Form
Liquid
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 0.2% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-13736 targets CD137 in FACS and IF applications and shows reactivity with Human samples.
The MA5-13736 immunogen is ectodomain of human 4-1BB recombinant protein.
Target Information
CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and dendritic cell development. Triggered CD137 induces a cytokine release profile regulating peripheral monocyte survival. Soluble forms of CD137 may provide negative control mechanism for some immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 4 1 BB; 4-1BB ligand receptor; 41BB; CD137 antigen; homolog of mouse 4-1BB; induced by lymphocyte activation (ILA); induced by lymphocyte activation; similar to Human receptor protein encoded by GenBank Accession Number U03397; interleukin-activated receptor, homolog of mouse Ly63; receptor protein 4-1BB; s4 1 BB; s4 1BB; s41BB; sCD137; soluble 4 1 BB; soluble 4 1BB; soluble 41BB; soluble CD137; T cell antigen ILA; T-cell antigen 4-1BB homolog; unnamed protein product
Gene Aliases: 4-1BB; CD137; CDw137; ILA; IMD109
UniProt ID: (Human) Q07011
Entrez Gene ID: (Human) 3604
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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