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Invitrogen

INSR alpha Monoclonal Antibody (83-14), Biotin

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INSR alpha Monoclonal Antibody (83-14), Biotin

Product Details

MA5-13756

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

1:10-1:100
-

ELISA (ELISA)

Assay-dependent
-

Immunoprecipitation (IP)

2 µg/mL
View 3 publications 3 publications

Neutralization (Neu)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

83-14

Immunogen

IM-9 lymphocytes followed by purified insulin receptor
3D Epitope / Immunogen

Conjugate

Biotin Biotin Biotin

Form

Liquid

Concentration

0.2 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.4, with 0.2% BSA

Contains

0.09% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10990056

Product Specific Information

MA5-13756 targets Insulin Receptor alpha in WB, ICC/IF, ELISA and IP applications and shows reactivity with Human samples.

The MA5-13756 immunogen is iM-9 lymphocytes followed by purified insulin receptor.

Target Information

Biological actions of insulin and IGF-1 are mediated by their respective cell surface receptor tyrosine kinases that regulate multiple signaling pathways through activation of a series of phosphorylation cascades. The insulin receptor. Insulin/IGF-1 binding to the extracellular domain leads to autophosphorylation of downstream target proteins. These two receptors differ in sequence in regions that confer specificity for the designated ligand as well as in certain intracellular signaling domains, resulting in significant differences in the functional consequences of activation of each receptor. Defects in IR are the cause of various insulin resistance syndromes and IGF-1R defects may cause some forms of growth retardation. Both these signaling cascades are also important for the development of cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: CD220 beta; insulin receptor precursor; IR; IR alpha; IR beta; unnamed protein product

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Gene Aliases: CD220; HHF5

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UniProt ID: (Human) P06213

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Entrez Gene ID: (Human) 3643

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Function(s)
beta-amyloid binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity insulin-activated receptor activity insulin-like growth factor receptor binding structural molecule activity protein binding ATP binding GTP binding protein domain specific binding protein kinase activator activity insulin-like growth factor I binding insulin-like growth factor II binding cargo receptor activity identical protein binding phosphatidylinositol 3-kinase binding insulin binding insulin receptor substrate binding macromolecular complex binding PTB domain binding
Process(es)
positive regulation of receptor internalization heart morphogenesis regulation of glycogen biosynthetic process regulation of transcription, DNA-templated receptor-mediated endocytosis transmembrane receptor protein tyrosine kinase signaling pathway G-protein coupled receptor signaling pathway learning memory positive regulation of cell proliferation insulin receptor signaling pathway male gonad development regulation of gene expression regulation of glucose metabolic process adrenal gland development positive regulation of cell migration cellular response to insulin stimulus glucose homeostasis positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of protein complex disassembly positive regulation of MAPK cascade positive regulation of nitric oxide biosynthetic process positive regulation of glycogen biosynthetic process positive regulation of glycolytic process positive regulation of mitotic nuclear division positive regulation of transcription, DNA-templated regulation of embryonic development positive regulation of glucose import viral entry into host cell protein autophosphorylation animal organ development positive regulation of developmental growth system development positive regulation of cellular component organization regulation of multicellular organismal process positive regulation of meiotic cell cycle positive regulation of protein kinase B signaling positive regulation of respiratory burst dendritic spine maintenance beta-amyloid clearance transport across blood-brain barrier neuron projection maintenance regulation of female gonad development
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